Evidence map›Paper›PMID 38218967›Full record

ArticleNature communications2024

Digital automation of transdermal drug delivery with high spatiotemporal resolution.

Yihang Wang, Zeka Chen, Brayden Davis, Will Lipman, Sicheng Xing, Lin Zhang, Tian Wang, Priyash Hafiz, Wanrong Xie, Zijie Yan and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Yihang Wang *Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zeka Chen *Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Brayden DavisUNC/NCSU Joint Department of Biomedical Engineering, Chapel Hill, NC, 27599, USA.
Will LipmanDepartment of Psychology and Neuroscience, University of North Carolina at chapel Hill, Chapel Hill, NC, 27599, USA.
Sicheng XingUNC/NCSU Joint Department of Biomedical Engineering, Chapel Hill, NC, 27599, USA.ORCID 0009-0004-8227-2217
Lin ZhangDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Tian WangUNC/NCSU Joint Department of Biomedical Engineering, Chapel Hill, NC, 27599, USA.
Priyash HafizUNC/NCSU Joint Department of Biomedical Engineering, Chapel Hill, NC, 27599, USA.
Wanrong XieDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zijie YanDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zhili HuangState Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032, China.ORCID 0000-0001-9359-1150
Juan SongDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. juansong@email.unc.edu.ORCID 0000-0002-7836-343X
Wubin BaiDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. wbai@unc.edu.ORCID 0000-0003-2872-5559
University of North Carolina at Chapel Hill · USUNC/NCSU Joint Department of Biomedical Engineering · USFudan University · CN

Funding

Sex-dependent role of 5HT1A receptors in adult neurogenesis and hippocampal functionR01MH122692 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2020 to 2024
$2.9M
Role of Cholecystokinin in the Dentate GyrusR01NS121300 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2021 to 2025
$2.3M
Regulation and functional contribution of hypothalamic modified adult hippocampal neurogenesisR01MH132222 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2023 to 2025
$2.3M
Enhancing adult-born neurons to restore brain functions in Alzheimer's diseaseR01AG084207 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2023 to 2025
$2.1M
Glutamatergic neural circuit modulation for treating Alzheimer’s diseaseRF1AG071000 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2021 to 2021
$1.9M
Wearable, Wireless Deep-tissue Sensing Patch for Continuous Monitoring of Recovery from Microsurgical Tissue TransferR01EB034332 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wubin Bai · 2023 to 2026
$1.3M
National Science FoundationNIA NIH HHS R01 AG084207NIA NIH HHS RF1 AG071000NIBIB NIH HHS R01 EB034332NIMH NIH HHS R01 MH122692NIMH NIH HHS R01 MH132222NINDS NIH HHS R01 NS121300University of North Carolina at Chapel Hill
6 · The paper itself

Abstract

Transdermal drug delivery is of vital importance for medical treatments. However, user adherence to long-term repetitive drug delivery poses a grand challenge. Furthermore, the dynamic and unpredictable disease progression demands a pharmaceutical treatment that can be actively controlled in real-time to ensure medical precision and personalization. Here, we report a spatiotemporal on-demand patch (SOP) that integrates drug-loaded microneedles with biocompatible metallic membranes to enable electrically triggered active control of drug release. Precise control of drug release to targeted locations (<1 mm

Indexed as

Drug Delivery SystemsSkinAdministration, CutaneousAnimalsDrug LiberationMiceNeedlesPharmaceutical PreparationsPharmaceutical Preparations

Identifiers

PMID38218967
PMCPMC10787768
OpenAlexW4390841533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.