Evidence map›Paper›PMID 38218908›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2024

Transpyloric feeding is associated with adverse in-hospital outcomes in infants with severe bronchopulmonary dysplasia.

Jonathan C Levin, Matthew J Kielt, Lystra P Hayden, Sara Conroy, William E Truog, Milenka Cuevas Guaman, Steven H Abman, Leif D Nelin, Rachel L Rosen, Kristen T Leeman

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06821776 (N-of-1 Trial Comparing Prolonged Gastric Feeding to Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06821776 narecruitingnot on this mapstarted 2025, after this paper: background citation

N-of-1 Trial Comparing Prolonged Gastric Feeding to Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia

TypeinterventionalSponsorLe Bonheur Children's HospitalRan2025 to 2030Enrolled25ConditionsBronchopulmonary Dysplasia, Feeding IntoleranceArmsGastric feeding, Transpyloric feeding
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Association between route of furosemide administration and diuretic response in very preterm infants with bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. Toward precision for bronchopulmonary dysplasia: Moving past current definitions.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  3. Article
  4. Gastroesophageal reflux during postpyloric versus gastric tube feeding in preterm infants with bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Observational
  5. Transpyloric feeding in severe BPD: a call for prospective trials.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jonathan C LevinBoston Children's Hospital and Harvard Medical School, Boston, MA, USA. Jonathan.Levin@childrens.harvard.edu.ORCID 0000-0002-8422-791X
Matthew J KieltNationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.ORCID 0000-0002-4568-9070
Lystra P HaydenBoston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6874-0097
Sara ConroyNationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.ORCID 0000-0001-9155-9456
William E TruogChildren's Mercy Hospital and University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
Milenka Cuevas GuamanTexas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-3835-5806
Steven H AbmanChildren's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-7292-2085
Leif D NelinNationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.ORCID 0000-0002-3722-3035
Rachel L RosenBoston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Kristen T LeemanBoston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3410-9675
Boston Children's Hospital · USNationwide Children's Hospital · USBaylor College of Medicine · USChildren's Hospital Colorado · USChildren's Mercy Hospital · US

Funding

Genetic Epidemiology of Respiratory Function in Former Preterm ChildrenK23HL136851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAYDEN, LYSTRA P. · 2018 to 2022
$969k
NHLBI NIH HHS K23 HL136851
6 · The paper itself

Abstract

objectiveTo estimate the association of transpyloric feeding (TPF) with the composite outcome of tracheostomy or death for patients with severe bronchopulmonary dysplasia (sBPD). STUDY

designRetrospective multi-center cohort study of preterm infants <32 weeks with sBPD receiving enteral feedings. We compared infants who received TPF at 36, 44, or 50 weeks post-menstrual age to those who did not receive TPF at any of those timepoints. Odds ratios were adjusted for gestational age, small for gestational age, male sex, and invasive ventilation and FiO

resultsAmong 1039 patients, 129 (12%) received TPF. TPF was associated with an increased odds of tracheostomy or death (aOR 3.5, 95% CI 2.0-6.1) and prolonged length of stay or death (aOR 3.1, 95% CI 1.9-5.2).

conclusionsUse of TPF in sBPD after 36 weeks was infrequent and associated with worse in-hospital outcomes, even after adjusting for respiratory severity at 36 weeks.

Indexed as

Bronchopulmonary DysplasiaInfant, PrematureCohort StudiesFemaleGestational AgeHumansInfant, NewbornIntensive Care Units, NeonatalMaleRetrospective Studies

Identifiers

PMID38218908
OpenAlexW4390841056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.