Evidence map›Paper›PMID 38218889›Full record

ArticleClinical epigenetics2024

Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia.

Xiuqin Bao, Yuanyi Gao, Zhongju Wang, Yuhua Ye, Diyu Chen, Yangjin Zuo, Cunyou Zhao, Xiangmin Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiuqin BaoMedical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, 514000, Guangdong, China.
Yuanyi GaoInnovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Zhongju WangDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Yuhua YeDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Diyu ChenDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Yangjin ZuoDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Cunyou ZhaoDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China. zhaocunyou@gmail.com.
Xiangmin XuInnovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. gzxuxm@pub.guangzhou.gd.cn.
Southern Medical University · CNKey Laboratory of Guangdong Province · CNGuangdong Province Women and Children Hospital · CNNanfang Hospital · CN

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515220207 and 2023A1515010254Guangzhou Municipal Science and Technology Project 202201011361National Key Research and Development Program of China 2018YFA0507800 and 2018YFA0507803National Natural Science Foundation of China 82100136
6 · The paper itself

Abstract

The mechanism that drives the switch from fetal to adult hemoglobin (Hb) provides a therapeutic target for β-thalassemia. We have previously identified that hypermethylation of transcription factor ERF promoter reactivated γ-globin expression. To uncover the mechanism underlying the hypermethylation of ERF promoter, we performed RNA sequencing in β

Indexed as

beta-ThalassemiaRNA, Long NoncodingAdultDNA MethylationFetal Hemoglobingamma-GlobinsHumansRepressor ProteinsERF protein, humanFetal Hemoglobingamma-GlobinsRepressor ProteinsRNA, Long NoncodingERF promoter hypermethylationFetal hemoglobinRP11-196G18.23β-Thalassemiaγ-Globin

Identifiers

PMID38218889
PMCPMC10787479
OpenAlexW4390838968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.