Evidence map›Paper›PMID 38218552›Full record

ArticleFree radical biology & medicine2024

Sensitive simultaneous measurements of oxygenation and extracellular pH by EPR using a stable monophosphonated trityl radical and lithium phthalocyanine.

Chloe Buyse, Lionel Mignion, Nicolas Joudiou, Samia Melloul, Benoit Driesschaert, Bernard Gallez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Chloe BuyseBiomedical Magnetic Resonance Research Group (REMA), Louvain Drug Research Institute (LDRI), UCLouvain, Brussels, Belgium.
Lionel MignionNuclear and Electron Spin Technologies Platform (NEST), Louvain Drug Research Institute (LDRI), UCLouvain, Brussels, Belgium.
Nicolas JoudiouNuclear and Electron Spin Technologies Platform (NEST), Louvain Drug Research Institute (LDRI), UCLouvain, Brussels, Belgium.
Samia MelloulBiomedical Magnetic Resonance Research Group (REMA), Louvain Drug Research Institute (LDRI), UCLouvain, Brussels, Belgium.
Benoit DriesschaertDepartment of Pharmaceutical Sciences, School of Pharmacy & In Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV, USA.
Bernard GallezBiomedical Magnetic Resonance Research Group (REMA), Louvain Drug Research Institute (LDRI), UCLouvain, Brussels, Belgium. Electronic address: bernard.gallez@uclouvain.be.
Solvay (Belgium) · BEde Duve Institute · BEWest Virginia University · US

Funding

Biocompatible triarylmethyl radical-based dendrimers as nonmetallic contrast agents for MRIR01EB032321 · NIBIB · WEST VIRGINIA UNIVERSITY · PI DRIESSCHAERT, BENOIT · 2022 to 2025
$1.5M
Biocompatible Magnetic Resonance Probes for in vivo Concurrent Profiling R00EB023990 · NIBIB · WEST VIRGINIA UNIVERSITY · PI DRIESSCHAERT, BENOIT · 2019 to 2021
$730k
Imaging enzyme activity by Overhauser-enhanced MRIR21EB028553 · NIBIB · WEST VIRGINIA UNIVERSITY · PI DRIESSCHAERT, BENOIT · 2020 to 2022
$599k
Electron Spin Resonance Microfluidics as a new tool in chemical single cell population analysisR21GM143595 · NIGMS · WEST VIRGINIA UNIVERSITY · PI BLANK, AHARON, DRIESSCHAERT, BENOIT · 2022 to 2023
$387k
NIBIB NIH HHS R00 EB023990NIBIB NIH HHS R01 EB032321NIBIB NIH HHS R21 EB028553NIGMS NIH HHS R21 GM143595
6 · The paper itself

Abstract

The monitoring of acidosis and hypoxia is crucial because both factors promote cancer progression and impact the efficacy of anti-cancer treatments. A phosphonated tetrathiatriarylmethyl (pTAM) has been previously described to monitor both parameters simultaneously, but the sensitivity to tackle subtle changes in oxygenation was limited. Here, we describe an innovative approach combining the pTAM radical and lithium phthalocyanine (LiPc) crystals to provide sensitive simultaneous measurements of extracellular pH (pH

Indexed as

AcrylatesIndolesNeoplasmsOrganometallic CompoundsOxygenAnimalsElectron Spin Resonance SpectroscopyHydrogen-Ion ConcentrationMiceTumor Microenvironment2-cyano-3-(1-phenylindol-3-yl)acrylateAcrylatesIndoleslithium phthalocyanineOrganometallic CompoundsOxygenEPRESRHypoxiaIn vivoMetabolismMitochondriaOxygenationpHTumor microenvironment

Identifiers

PMID38218552
PMCPMC10923140
OpenAlexW4390755596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.