ArticleCell reports methods2024
Modulation of neuronal activity in cortical organoids with bioelectronic delivery of ions and neurotransmitters.
Article in Cell reports methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience.Advanced healthcare materials · 2026Pooled it
- Establishing mouse forebrain organoids as models of intrinsic cortical network assembly.Stem cell reports · 2026Article
- A modular platform for automated organoid culture and longitudinal imaging.Scientific reports · 2026Article
- Live-cell physiology in human brain tissue culture-the potential, the challenges, and the lessons learned.Frontiers in cellular neuroscience · 2026Review
- Cell-type-resolvedbioRxiv : the preprint server for biology · 2025Article
- Article
- Harnessing Intelligence from Brain Cells In Vitro.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- The emergence of electrical activity in human brain organoids.Stem cell reports · 2025Review
- A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring.Internet of things (Amsterdam, Netherlands) · 2025Article
- Fate plasticity of interneuron specification.iScience · 2025Article
- Miniaturized Iontronic Micropipettes for Precise and Dynamic Ionic Modulation of Neuronal and Astrocytic Activity.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Bioelectronic Delivery of Potassium Ions Controls Membrane Voltage and Growth Dynamics in Bacteria Biofilms.Biomedical materials & devices (New York, N.Y.) · 2025Article
- Meeting Review: "National Cancer Institute Conference on Cancer Bioelectricity" September 12, 2024.Bioelectricity · 2025Review
- Multiscale Cloud-Based Pipeline for Neuronal Electrophysiology Analysis and Visualization.bioRxiv : the preprint server for biology · 2024Article
- More on Pulsed Electric Fields, and More….Bioelectricity · 2024Article
- Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education.eNeuro · 2023Article
- Internet-connected cortical organoids for project-based stem cell and neuroscience education.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
18 authors at 2 institutions in 2 countries.
Funding
Abstract
Precise modulation of brain activity is fundamental for the proper establishment and maturation of the cerebral cortex. To this end, cortical organoids are promising tools to study circuit formation and the underpinnings of neurodevelopmental disease. However, the ability to manipulate neuronal activity with high temporal resolution in brain organoids remains limited. To overcome this challenge, we introduce a bioelectronic approach to control cortical organoid activity with the selective delivery of ions and neurotransmitters. Using this approach, we sequentially increased and decreased neuronal activity in brain organoids with the bioelectronic delivery of potassium ions (K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.