Evidence map›Paper›PMID 38217856›Full record

ArticleCell reports2024

A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models.

Alicia M Bedolla, Gabriel L McKinsey, Kierra Ware, Nicolas Santander, Thomas D Arnold, Yu Luo

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Alicia M BedollaDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA.
Gabriel L McKinseyDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Kierra WareDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA.
Nicolas SantanderInstituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile.
Thomas D ArnoldDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Yu LuoDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45229, USA; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center. Electronic address: luoy2@ucmail.uc.edu.
University of California, San Francisco · USUniversity of Cincinnati · USCincinnati Children's Hospital Medical Center · USUniversity of O'Higgins · CL

Funding

ENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9M
PREDOCTORAL TRAINING PROGRAM IN THE NEUROSCIENCEST32NS007453 · NINDS · UNIVERSITY OF CINCINNATI · PI HERMAN, JAMES P · 1997 to 2025
$4.0M
Defective heme transport in the development of congenital hydrocephalusR01NS123168 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD, THOMAS DARMODY · 2021 to 2025
$3.1M
Investigating the role of CSF production and circulation in aging and Alzheimer's diseaseR01AG083164 · NIA · UNIVERSITY OF CINCINNATI · PI Yu Luo · 2023 to 2026
$2.6M
The role TGF-beta Signaling pathway in microglia and astrocytes homeostasis and cellular interactionsR01NS125074 · NINDS · UNIVERSITY OF CINCINNATI · PI Yu Luo · 2022 to 2026
$2.6M
How do CNS fibroblasts regulate the response to neuroinflammation?R01NS119615 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DANEMAN, RICHARD · 2021 to 2025
$2.4M
Modulating a critical inhibitory proteoglycan receptor to promote functional recovery after strokeR01NS107365 · NINDS · UNIVERSITY OF CINCINNATI · PI LUO, YU, SILVER, JERRY · 2019 to 2022
$1.4M
Leica Stellaris 8 Confocal MicroscopeS10OD030402 · OD · UNIVERSITY OF CINCINNATI · PI HONG, CHRISTIAN I · 2021 to 2021
$598k
Ablating choroid plexus epithelial cells in the developing mouse brain: A new tool to approach CSF disordersR21NS127177 · NINDS · UNIVERSITY OF CINCINNATI · PI GOTO, JUNE, LUO, YU · 2022 to 2022
$457k
A Dual Role of Activin-like kinase 5 (ALK5)-mediated TGF Beta Signaling in Adult NeurogenesisF31NS129204 · NINDS · UNIVERSITY OF CINCINNATI · PI WARE, KIERRA · 2023 to 2025
$83k
The Role of Activin-like kinase 5 (ALK5) for maintaining microglia and astrocyte homeostasis and activationF31NS125930 · NINDS · UNIVERSITY OF CINCINNATI · PI BEDOLLA, ALICIA MARIE · 2022 to 2023
$80k
NIA NIH HHS R01 AG083164NIH HHS S10 OD030402NINDS NIH HHS F31 NS125930NINDS NIH HHS F31 NS129204NINDS NIH HHS R01 NS107365NINDS NIH HHS R01 NS119615NINDS NIH HHS R01 NS123168NINDS NIH HHS R01 NS125074NINDS NIH HHS R21 NS127177NINDS NIH HHS T32 NS007453
6 · The paper itself

Abstract

The recent proliferation of new Cre and CreER recombinase lines provides researchers with a diverse toolkit to study microglial gene function. To determine how best to apply these lines in studies of microglial gene function, a thorough and detailed comparison of their properties is needed. Here, we examined four different microglial CreER lines (Cx3cr1

Indexed as

IntegrasesMicrogliaAnimalsDisease Models, AnimalMiceMice, TransgenicTamoxifenIntegrasesTamoxifenCP: NeuroscienceCre recombinaseCX3CR1inducible gene recombinationmicrogliaP2RY12tmem119

Identifiers

PMID38217856
PMCPMC10874587
OpenAlexW4390815458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.