ArticleJournal of medical systems2024
Artificial Intelligence-enabled Chest X-ray Classifies Osteoporosis and Identifies Mortality Risk.
Article in Journal of medical systems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Deep learning-based evaluation of panoramic radiographs for osteoporosis screening: a systematic review and meta-analysis.BMC medical imaging · 2025Pooled it
- Diagnostic accuracy of chest X-ray and CT using artificial intelligence for osteoporosis: systematic review and meta-analysis.Journal of bone and mineral metabolism · 2024Pooled it
- IgeaNet: a deep learning model for opportunistic osteoporosis screening from chest X-ray images.La Radiologia medica · 2026Article
- Transparent chest radiograph foundation model enables explainable human disease profiling.NPJ digital medicine · 2026Article
- Clinical impact of adopting an AI-driven opportunistic bone health screening software using routine X-ray.Skeletal radiology · 2026Article
- Consensus statement on the application of artificial intelligence in osteoporosis screening and management: perspectives from the Asia-Pacific region.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Enhancing Parkinson's Disease Staging: An Integrative Deep Learning Framework for Multimodal Feature Selection.Journal of molecular neuroscience : MN · 2026Article
- Prediction of Future Risk of Moderate to Severe Kidney Function Loss Using a Deep Learning Model-Enabled Chest Radiography.Journal of imaging informatics in medicine · 2026Article
- Artificial Intelligence in Rheumatology: From Algorithms to Clinical Impact in Osteoporosis and Chronic Inflammatory Rheumatic Diseases.Journal of clinical medicine · 2026Article
- Explainable opportunistic osteoporosis screening from chest X-rays: a retrospective comparison of foundation models.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Artificial Intelligence for Osteoporosis Diagnosis, Risk Prediction and Therapy: Current Advances, Clinical Challenges, and Future Perspectives.Clinical interventions in aging · 2026Review
- Performance evaluation of deep learning-based osteoporosis diagnostic models with conventional chest X-ray in a clinical cohort.Journal of thoracic disease · 2025Article
- Transfer learning based osteoporosis prediction using enhanced medical imaging and fuzzy fusion.Scientific reports · 2025Article
- Deep‑learning based osteoporosis classification in knee X‑rays using transfer‑learning approach.Scientific reports · 2025Article
- Real-world application of deep learning for ECG-based prediction of coronary artery disease and revascularization needs.European heart journal. Digital health · 2025Article
- Fusion of X-Ray Images and Clinical Data for a Multimodal Deep Learning Prediction Model of Osteoporosis: Algorithm Development and Validation Study.JMIR medical informatics · 2025Article
- Barriers and solutions for global access to osteoporosis management: a Position Paper from the International Osteoporosis Foundation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Machine learning is changing osteoporosis detection: an integrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Applying Deep-Learning Algorithm Interpreting Kidney, Ureter, and Bladder (KUB) X-Rays to Detect Colon Cancer.Journal of imaging informatics in medicine · 2025Article
- Prevention of Osteoporosis in SAMP6 Mice by Rikkunshi-To: Japanese Kampo Medicine.Life (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A deep learning model was developed to identify osteoporosis from chest X-ray (CXR) features with high accuracy in internal and external validation. It has significant prognostic implications, identifying individuals at higher risk of all-cause mortality. This Artificial Intelligence (AI)-enabled CXR strategy may function as an early detection screening tool for osteoporosis. The aim of this study was to develop a deep learning model (DLM) to identify osteoporosis via CXR features and investigate the performance and clinical implications. This study collected 48,353 CXRs with the corresponding T score according to Dual energy X-ray Absorptiometry (DXA) from the academic medical center. Among these, 35,633 CXRs were used to identify CXR- Osteoporosis (CXR-OP). Another 12,720 CXRs were used to validate the performance, which was evaluated by the area under the receiver operating characteristic curve (AUC). Furthermore, CXR-OP was tested to assess the long-term risks of mortality, which were evaluated by Kaplan‒Meier survival analysis and the Cox proportional hazards model. The DLM utilizing CXR achieved AUCs of 0.930 and 0.892 during internal and external validation, respectively. The group that underwent DXA with CXR-OP had a higher risk of all-cause mortality (hazard ratio [HR] 2.59, 95% CI: 1.83-3.67), and those classified as CXR-OP in the group without DXA also had higher all-cause mortality (HR: 1.67, 95% CI: 1.61-1.72) in the internal validation set. The external validation set produced similar results. Our DLM uses CXRs for early detection of osteoporosis, aiding physicians to identify those at risk. It has significant prognostic implications, improving life quality and reducing mortality. AI-enabled CXR strategy may serve as a screening tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.