Evidence map›Paper›PMID 38217725›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Causal association of gastroesophageal reflux disease with chronic sinusitis and chronic disease of the tonsils and adenoids.

Weizhen Li, Yanan Zhang, Xinwei Li, Mengtong Xie, Lin Dong, Mengdi Jin, Qingxing Lu, Min Zhang, Fengyu Xue, Lintong Jiang and 1 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Weizhen LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Yanan ZhangDepartment of Hand and Podiatric Surgery, Orthopedics Center, the First Hospital of Jilin University, Changchun, 130021, China.
Xinwei LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Mengtong XieDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Lin DongDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Mengdi JinDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Qingxing LuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Min ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Fengyu XueDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Lintong JiangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Qiong YuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China. yuqiong@jlu.edu.cn.ORCID http://orcid.org/0000-0003-1143-1749
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExploring bidirectional causal associations between gastroesophageal reflux disease (GERD) and chronic disease of the tonsils and adenoids and chronic sinusitis, respectively.

methodsWe first conducted a TSMR (two-sample mendelian randomization) study using the results of the inverse variance weighting method as the primary basis and bidirectional MR to rule out reverse causation. Subsequently, MVMR (multivariate MR) analysis was performed to identify phenotypes associated with SNPs and to explore the independent effect of GERD on two outcomes. Finally, we calculated MR-Egger intercepts to assess horizontal polytropy and Cochran's Q statistic to assess heterogeneity and ensure the robustness of the study.

resultsFor each standard deviation increase in genetically predicted GERD rate, there was an increased risk of chronic disease of the tonsils and adenoids (OR 1.162, 95% CI 1.036-1.304, P: 1.06E-02) and of developing chronic sinusitis (OR 1.365, 95% CI 1.185-1.572, P: 1.52E-05), and there was no reverse causality. Causality for TSMR was obtained on the basis of IVW (inverse variance weighting) and appeared to be reliable in almost all sensitivity analyses, whereas body mass index may be a potential mediator of causality between GERD and chronic sinusitis.

conclusionThere is a causal association between GERD and chronic disease of the tonsils and adenoids and chronic sinusitis, respectively, and the occurrence of GERD increases the risk of developing chronic disease of the tonsils and adenoids and chronic sinusitis.

Indexed as

AdenoidsGastroesophageal RefluxSinusitisChronic DiseaseFemaleHumansMaleMendelian Randomization AnalysisPalatine TonsilPolymorphism, Single NucleotideCausalityChronic diseases of tonsils and adenoidsChronic sinusitisGastroesophageal reflux diseaseMendelian randomization

Identifiers

PMID38217725
OpenAlexW4390837933

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.