Evidence map›Paper›PMID 38217470›Full record

ArticleGut microbes

Influence of age, socioeconomic status, and location on the infant gut resistome across populations.

Dhrati V Patangia, Ghjuvan Grimaud, Shaopu Wang, R Paul Ross, Catherine Stanton

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Dhrati V PatangiaSchool of Microbiology, University College Cork, Cork, Ireland.
Ghjuvan GrimaudTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland.
Shaopu WangKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
R Paul RossSchool of Microbiology, University College Cork, Cork, Ireland.ORCID 0000-0003-4876-8839
Catherine StantonTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland.
Teagasc - The Irish Agriculture and Food Development Authority · IESichuan University · CNUniversity College Cork · IE

Funding

European Research Council 101054719
6 · The paper itself

Abstract

Antibiotic resistance is a growing global concern, with many ecological niches showing a high abundance of antibiotic resistance genes (ARGs), including the human gut. With increasing indications of ARGs in infants, this study aims to investigate the gut resistome profile during early life at a wider geographic level. To achieve this objective, we utilized stool samples data from 26 studies involving subjects aged up to 3 years from different geographical locations. The 32,277 Metagenome Assembled Genomes (MAGs) previously generated from shotgun sequencing reads from these studies were used for resistome analysis using RGI with the CARD database. This analysis showed that the distribution of ARGs across the countries in our study differed in alpha diversity and compositionally. In particular, the abundance of ARGs was found to vary by socioeconomic status and healthcare access and quality (HAQ) index. Surprisingly, countries having lower socioeconomic status and HAQ indices showed lower ARG abundance, which was contradictory to previous reports. Gram-negative genera, including

Indexed as

Gastrointestinal MicrobiomeGenes, BacterialAgedAnti-Bacterial AgentsDrug Resistance, MicrobialEscherichiaHumansInfantSocial ClassAnti-Bacterial AgentsInfant gut resistancemeta-analysisresistomeshotgun sequencing

Identifiers

PMID38217470
PMCPMC10793692
OpenAlexW4390838339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.