Evidence map›Paper›PMID 38217405›Full record

ArticleGigaScience2024

A multi-omics data analysis workflow packaged as a FAIR Digital Object.

Anna Niehues, Casper de Visser, Fiona A Hagenbeek, Purva Kulkarni, René Pool, Naama Karu, Alida S D Kindt, Gurnoor Singh, Robert R J M Vermeiren, Dorret I Boomsma and 3 more

Abstract read
In one paragraph

Article in GigaScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna NiehuesDepartment of Medical BioSciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-9839-5439
Casper de VisserDepartment of Medical BioSciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-2812-5898
Fiona A HagenbeekDepartment of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands.ORCID 0000-0002-8773-0430
Purva KulkarniDepartment of Medical BioSciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-4681-4582
René PoolDepartment of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands.ORCID 0000-0001-5579-0933
Naama KaruMetabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, 2333 AL Leiden, The Netherlands.ORCID 0000-0001-8005-0726
Alida S D KindtMetabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, 2333 AL Leiden, The Netherlands.ORCID 0000-0001-6551-6030
Gurnoor SinghDepartment of Medical BioSciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-1615-4197
Robert R J M VermeirenDepartment of Child and Adolescent Psychiatry, LUMC-Curium, Leiden University Medical Center, 2342 AK Oegstgeest, The Netherlands.ORCID 0000-0002-8673-2207
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands.ORCID 0000-0002-7099-7972
Jenny van DongenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands.ORCID 0000-0003-2063-8741
Peter A C 't HoenDepartment of Medical BioSciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-4450-3112
Alain J van GoolTranslational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.ORCID 0000-0003-0010-5286

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek
6 · The paper itself

Abstract

backgroundApplying good data management and FAIR (Findable, Accessible, Interoperable, and Reusable) data principles in research projects can help disentangle knowledge discovery, study result reproducibility, and data reuse in future studies. Based on the concepts of the original FAIR principles for research data, FAIR principles for research software were recently proposed. FAIR Digital Objects enable discovery and reuse of Research Objects, including computational workflows for both humans and machines. Practical examples can help promote the adoption of FAIR practices for computational workflows in the research community. We developed a multi-omics data analysis workflow implementing FAIR practices to share it as a FAIR Digital Object.

findingsWe conducted a case study investigating shared patterns between multi-omics data and childhood externalizing behavior. The analysis workflow was implemented as a modular pipeline in the workflow manager Nextflow, including containers with software dependencies. We adhered to software development practices like version control, documentation, and licensing. Finally, the workflow was described with rich semantic metadata, packaged as a Research Object Crate, and shared via WorkflowHub.

conclusionsAlong with the packaged multi-omics data analysis workflow, we share our experiences adopting various FAIR practices and creating a FAIR Digital Object. We hope our experiences can help other researchers who develop omics data analysis workflows to turn FAIR principles into practice.

Indexed as

MultiomicsSoftwareChildHumansMetadataReproducibility of ResultsWorkflowFAIRFDOmetadatamulti-omicsRO-Crateworkflow

Identifiers

PMID38217405
PMCPMC10787363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.