Evidence map›Paper›PMID 38217242›Full record

ArticleNature computational science2021

The Inflammatory Bowel Disease Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) framework.

Luca Massimino, Luigi Antonio Lamparelli, Yashar Houshyar, Silvia D'Alessio, Laurent Peyrin-Biroulet, Stefania Vetrano, Silvio Danese, Federica Ungaro

Abstract read
In one paragraph

Article in Nature computational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. TET1 deficiency amplifies macrophage inflammatory signaling associated with Crohn's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  6. Article
  7. Phytic acid (InsPNature communications · 2026
    Article
  8. Article
  9. Current research in food science · 2026
    Article
  10. Inactivation of glutathioneGut microbes · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luca Massimino *Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. admin@lucamassimino.com.ORCID http://orcid.org/0000-0003-3975-9148
Luigi Antonio Lamparelli *IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.ORCID http://orcid.org/0000-0002-9571-2582
Yashar HoushyarIBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Silvia D'AlessioPhoenixLAB, Lodi, Italy.
Laurent Peyrin-BirouletInserm NGERE, University of Lorraine, Vandoeuvre-les-Nancy, France.
Stefania VetranoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Silvio DaneseDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Federica UngaroDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. federica.ungaro@humanitasresearch.it.ORCID http://orcid.org/0000-0001-5395-7795

Funding

Fondazione Cariplo (Cariplo Foundation) 2018-0112 to FUInnovative Medicines Initiative (IMI) 853995 to SDInnovative Medicines Initiative (IMI) 853995 to SV
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a class of chronic disorders whose etiogenesis is still unknown. Despite the high number of IBD-related omics studies, the RNA-sequencing data produced results that are hard to compare because of the experimental variability and different data analysis approaches. We here introduce the IBD Transcriptome and Metatranscriptome Meta-Analysis (TaMMA) framework, a comprehensive survey of publicly available IBD RNA-sequencing datasets. IBD TaMMA is an open-source platform where scientists can explore simultaneously the freely available IBD-associated transcriptomics and microbial profiles thanks to its interactive interface, resulting in a useful tool to the IBD community.

Identifiers

PMID38217242
PMCPMC10766544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.