Evidence map›Paper›PMID 38216975›Full record

ArticleBMC complementary medicine and therapies2024

In vitro anti-HIV, cytotoxicity and nutritional analysis of Trianthema portulacastrum L. (Aizoaceae).

Mahboob Adekilekun Jimoh, Muhali Olaide Jimoh, Mujidat Bello, Idris Olawale Raimi, Gideon Olarewaju Okunlola, Nompumelelo Mkhwanazi, Charles Petrus Laubscher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Mahboob Adekilekun JimohDepartment of Plant Biology, Osun State University, P.M.B, Osogbo, 4494, Nigeria.
Muhali Olaide JimohDepartment of Horticultural Sciences, Faculty of Applied Sciences, Cape Peninsula University of Technology, Bellville, 7535, South Africa. muhali.jimoh@oouagoiwoye.edu.ng.
Mujidat BelloNational Biotechnology Development Agency, Lugbe, Abuja, Nigeria.
Idris Olawale RaimiDepartment of Botany, Obafemi Awolowo University, Ile-Ife, Nigeria.
Gideon Olarewaju OkunlolaDepartment of Plant Biology, Osun State University, P.M.B, Osogbo, 4494, Nigeria.
Nompumelelo MkhwanaziHIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, 4013, South Africa.
Charles Petrus LaubscherDepartment of Horticultural Sciences, Faculty of Applied Sciences, Cape Peninsula University of Technology, Bellville, 7535, South Africa.
Cape Peninsula University of Technology · ZAOsun State University · NGNational Biotechnology Development AgencyObafemi Awolowo University · NGUniversity of KwaZulu-Natal · ZA

Funding

Poliomyelitis Research Foundation through the University of KwaZulu Natal NPM- 21/76
6 · The paper itself

Abstract

The development of antiretroviral therapy has brought a tremendous relief to the world as it minimizes mortality, reduces HIV transmission, and suppresses progression in infected patients. However, the orthodox antiretroviral therapy is faced with limitations which have necessitated a continuous search for more novel plant-based antiviral compounds, which can bypass the existing barriers created by drug resistance and target more viral proteins. Despite the edibility and enormous pharmacological benefits of T. portulacastrum, little is known about its nutrient profiles and potential use as a natural source of antiviral drug. This study focuses on the full feed analysis and anti-HIV potential of two biotypes of T. portulacastrum. Ethanolic extracts of both biotypes of T. portulacastrum (T01 and T02) had significant inhibitory effects on the level of replication of the HIV-1. Both extracts induced the inhibition of at least 50% of the HIV-1 viral load at considerably low IC

Indexed as

AizoaceaeHIV InfectionsAntiviral AgentsHumansMineralsPlant ExtractsAntiviral AgentsMineralsPlant ExtractsAizoaceaeAntiretroviral drugsAntiviral nutrientsBotanical ingredientsTrianthema portulacastrum

Identifiers

PMID38216975
PMCPMC10785464
OpenAlexW4390827536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.