Evidence map›Paper›PMID 38216961›Full record

ArticleAlzheimer's research & therapy2024

Diagnostic accuracy of research criteria for prodromal frontotemporal dementia.

Alberto Benussi, Enrico Premi, Mario Grassi, Antonella Alberici, Valentina Cantoni, Stefano Gazzina, Silvana Archetti, Roberto Gasparotti, Giorgio G Fumagalli, Arabella Bouzigues and 38 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

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  11. Blood-Based Biomarkers in Frontotemporal Dementia: A Narrative Review.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 10 countries.

Alberto BenussiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy.
Enrico PremiVascular Neurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
Mario GrassiDepartment of Brain and Behavioral Science, Medical and Genomic Statistics Unit, University of Pavia, 27100, Pavia, Italy.
Antonella AlbericiNeurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
Valentina CantoniDepartment of Molecular and Translational Medicine, University of Brescia, 25123, Brescia, Italy.
Stefano GazzinaDepartment of Neurological and Vision Sciences, Neurophysiology Unit, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
Silvana ArchettiBiotechnology Laboratory, Department of Diagnostics, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
Roberto GasparottiDepartment of Medical and Surgical Specialties, Neuroradiology Unit, University of Brescia, 25123, Brescia, Italy.
Giorgio G FumagalliCenter for Mind/Brain Sciences-CIMeC, University of Trento, 38068, Rovereto, Italy.
Arabella BouziguesDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Lucy L RussellDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Kiran SamraDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
David M CashDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Martina BocchettaDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Emily G ToddDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Rhian S ConveryDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Imogen SwiftDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Aitana Sogorb-EsteveDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Carolin HellerDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
John C van SwietenDepartment of Neurology, Erasmus Medical Centre, Rotterdam, 3015 GD, The Netherlands.
Lize C JiskootDepartment of Neurology, Erasmus Medical Centre, Rotterdam, 3015 GD, The Netherlands.
Harro SeelaarDepartment of Neurology, Erasmus Medical Centre, Rotterdam, 3015 GD, The Netherlands.
Raquel Sanchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, 08036, Barcelona, Spain.
Fermin MorenoCognitive Disorders Unit, Department of Neurology, Donostia University Hospital, 20014, San Sebastian, Gipuzkoa, Spain.
Robert Jr LaforceClinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Facultéde Médecine, Université Laval, Quebec City, Québec, G1V 0A6, Canada.
Caroline GraffCenter for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet, 141 52, Solna, Sweden.
Matthis SynofzikDepartment of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, 72076, Tubingen, Germany.
Daniela GalimbertiFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122, Milan, Italy.
James B RoweDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust and Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, CB2 7EF, UK.
Mario MasellisSunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, ON, M4N 3M5, Canada.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, M5S, Canada.
Elizabeth FingerDepartment of Clinical Neurological Sciences, University of Western Ontario, London, ON, N6A 3K7, Canada.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, 3001, Leuven, Belgium.
Alexandre MendonçaFaculty of Medicine, University of Lisbon, 1649-028, Lisbon, Portugal.
Pietro TiraboschiFondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy.
Chris R ButlerNuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, OX3 9DU, UK.
Isabel SantanaNeurology Service, Faculty of Medicine, University Hospital of Coimbra (HUC), University of Coimbra, 3004-561, Coimbra, Portugal.
Alexander GerhardDivision of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, M20 3LJ, UK.
Isabelle Le BerSorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, 75013, Paris, France.
Florence PasquierUniv Lille, 59000, Lille, France.
Simon DucharmeDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, H3A 1A1, Canada.
Johannes LevinNeurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, 80539, Munich, Germany.
Sandro SorbiDepartment of Neurofarba, University of Florence, 50139, Florence, Italy.
Markus OttoDepartment of Neurology, University of Ulm, 89081, Ulm, Germany.
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy.
Jonathan D Rohrer *Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Barbara Borroni *Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy. bborroni@inwind.it.
Genetic Frontotemporal dementia Initiative (GENFI)
UK Dementia Research Institute · GBAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITErasmus University Rotterdam · NLUniversity of Brescia · ITUniversity of Coimbra · PTGerman Center for Neurodegenerative Diseases · DEKarolinska University Hospital · SEUniversity of Trento · ITBiogipuzkoa Health Research Institute · ESCentre National de la Recherche Scientifique · FRConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESDon Carlo Gnocchi Foundation · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITInserm · FRKU Leuven · BEMontreal Neurological Institute and Hospital · CAMRC Cognition and Brain Sciences Unit · GBMunich Cluster for Systems Neurology · DESalford Royal NHS Foundation Trust · GBSunnybrook Health Science Centre · CA

Funding

Medical Research Council MR/M008525/1Medical Research Council MR/M023664/1Medical Research Council MR/T046015/1
6 · The paper itself

Abstract

backgroundThe Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls.

methodsA total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment.

resultsThe core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001).

conclusionsThe proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD.

Indexed as

Frontotemporal DementiaAtrophyBiomarkersHumansNeurofilament ProteinsBiomarkersNeurofilament ProteinsDiagnostic accuracyDiagnostic criteriaFrontotemporal dementiaMCBMIProdromal

Identifiers

PMID38216961
PMCPMC10785469
OpenAlexW4390825876

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.