Evidence map›Paper›PMID 38216935›Full record

ReviewVirology journal2024

Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications.

Arash Letafati, Omid Salahi Ardekani, Mina Naderisemiromi, Mehdi Norouzi, Mohammadreza Shafiei, Soheil Nik, Sayed-Hamidreza Mozhgani

Abstract readReview
In one paragraph

Review in Virology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Single-cell and spatial transcriptomics reveal mTOR-driven cellular fate of spindle cells and immune evasion in classic Kaposi's sarcoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. The Dual Role of Natural Killer Cells in the Septic Liver.Journal of inflammation research · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Oncolytic viruses as cancer therapeutics: From mechanistic insights to clinical translation.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arash LetafatiDepartment of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Omid Salahi ArdekaniResearch Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran.
Mina NaderisemiromiDepartment of Immunology, Faculty of Medicine and Health, The University of Manchester, Manchester, UK.
Mehdi NorouziDepartment of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadreza ShafieiSchool of Medicine, Alborz University of Medical Sciences, Karaj, Alborz, Iran.
Soheil NikSchool of Medicine, Alborz University of Medical Sciences, Karaj, Alborz, Iran.
Sayed-Hamidreza MozhganiResearch Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran. hamidrezamozhgani@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses pose a constant threat to human well-being, necessitating the immune system to develop robust defenses. Natural killer (NK) cells, which play a crucial role in the immune system, have become recognized as vital participants in protecting the body against viral infections. These remarkable innate immune cells possess the unique ability to directly recognize and eliminate infected cells, thereby contributing to the early control and containment of viral pathogens. However, recent research has uncovered an intriguing phenomenon: the alteration of NK cells during viral infections. In addition to their well-established role in antiviral defense, NK cells undergo dynamic changes in their phenotype, function, and regulatory mechanisms upon encountering viral pathogens. These alterations can significantly impact the effectiveness of NK cell responses during viral infections. This review explores the multifaceted role of NK cells in antiviral immunity, highlighting their conventional effector functions as well as the emerging concept of NK cell alteration in the context of viral infections. Understanding the intricate interplay between NK cells and viral infections is crucial for advancing our knowledge of antiviral immune responses and could offer valuable information for the creation of innovative therapeutic approaches to combat viral diseases.

Indexed as

Virus DiseasesVirusesHumansKiller Cells, NaturalAntiviral immunityChronic infectionInnate immune responseNatural killer cellsNK cell alterationViral infections

Identifiers

PMID38216935
PMCPMC10785350

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.