Evidence map›Paper›PMID 38216882›Full record

ArticleBMC infectious diseases2024

Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013-2015).

Saravanan S R Sundaramurthy, Kristen E Allen, Mark A Fletcher, Kok Fui Liew, Boekhtiar Borhanuddin, Mohammad Ali, Graciela Morales, Bradford Gessner, Jerusha Naidoo, Jo Southern

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Saravanan S R SundaramurthyMalaysian Association for Family and Child Health (MAFCH), Kuala Lumpur, Malaysia. sharavanyad@gmail.com.
Kristen E AllenVaccines Medical and Scientific Affairs, Pfizer Biopharma, Collegeville, Pennsylvania, USA.
Mark A FletcherEmerging Markets Region Medical Affairs, Pfizer Biopharma, New York City, USA.
Kok Fui LiewPfizer Biopharma, Kuala Lumpur, Malaysia.
Boekhtiar BorhanuddinMalaysian Association for Family and Child Health (MAFCH), Kuala Lumpur, Malaysia.
Mohammad AliVaccines Medical and Scientific Affairs, Pfizer Biopharma, Collegeville, Pennsylvania, USA.
Graciela MoralesEmerging Markets Region Medical Affairs, Pfizer Biopharma, New York City, USA.
Bradford GessnerVaccines Medical and Scientific Affairs, Pfizer Biopharma, Collegeville, Pennsylvania, USA.
Jerusha NaidooEmerging Markets Region Medical Affairs, Pfizer Biopharma, New York City, USA.
Jo SouthernVaccines Medical and Scientific Affairs, Pfizer Biopharma, Collegeville, Pennsylvania, USA.
Pfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPneumococcal disease caused by Streptococcus pneumoniae is an important cause of morbidity and mortality across all ages, particularly in younger children and older adults. Here, we describe pneumococcal disease hospitalizations at Ministry of Health (MoH) facilities in Malaysia between 2013 and 2015.

methodsThis was a retrospective databases analysis. Tabular data from the Malaysian Health Data Warehouse (MyHDW) were used to identify microbiologically confirmed, pneumococcal disease hospitalizations and deaths during hospitalization, using hospital-assigned ICD-10 codes (i.e., classified as meningitis, pneumonia, or non-meningitis non-pneumonia). Case counts, mortality counts, and case fatality rates were reported by patient age group and by Malaysian geographic region.

resultsA total of 683 pneumococcal disease hospitalizations were identified from the analysis: 53 pneumococcal meningitis hospitalizations (5 deaths and 48 discharges), 413 pneumococcal pneumonia hospitalizations (24 deaths and 389 discharges), and 205 non-meningitis non-pneumonia pneumococcal disease hospitalizations (58 deaths and 147 discharges). Most hospitalizations occurred in children aged < 2 years. Crude mortality was highest among children aged < 2 years (for all three disease categories), among adults aged ≥ 65 years (for pneumococcal pneumonia), or among adults aged 65-85 years (for non-meningitis non-pneumonia pneumococcal disease). The case fatality rate, all ages included, was 5.8% for pneumococcal pneumonia, 9.1% for pneumococcal meningitis, and 28.3% for non-meningitis non-pneumonia pneumococcal disease.

conclusionsOur study is the first to document pneumococcal disease hospitalizations and deaths during hospitalization in Malaysia. Although this database analysis likely underestimated case counts, and the true disease burden could be even greater, the study demonstrates a substantial burden of pneumococcal disease. Public health measures, including vaccination, would significantly contribute to the prevention of hospitalizations and deaths associated with pneumococcal disease in Malaysia.

Indexed as

Meningitis, PneumococcalPneumococcal InfectionsPneumonia, PneumococcalAgedChildDelivery of Health CareHospitalizationHumansInfantPneumococcal VaccinesRetrospective StudiesStreptococcus pneumoniaePneumococcal VaccinesBacteraemiaMalaysiaMeningitisPneumococcalPneumoniaSepticaemia

Identifiers

PMID38216882
PMCPMC10790256
OpenAlexW4390829111

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.