Evidence map›Paper›PMID 38216872›Full record

Trial reportBMC neurology2024

Validity of the modified Rankin Scale in patients with aneurysmal subarachnoid hemorrhage: a randomized study.

E Nobels-Janssen, E N Postma, I L Abma, J M C van Dijk, I R de Ridder, H Schenck, W A Moojen, M H den Hertog, D Nanda, A R E Potgieser and 6 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Blood pressure variability in the ATACH2 study: evaluating a target range.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

E Nobels-JanssenDepartment of Neurology, Haga Teaching Hospital, The Hague, The Netherlands. edith.nobels-janssen@radboudumc.nl.ORCID http://orcid.org/0000-0001-9725-2842
E N PostmaAmsterdam UMC, Department of Neurosurgery, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
I L AbmaIQ healthcare and Department of Rehabilitation, Radboud University Medical Center, Radboud Institute of Health Sciences, Nijmegen, The Netherlands.
J M C van DijkDepartment of Neurosurgery, University Medical Center Groningen, Groningen, The Netherlands.
I R de RidderDepartment of Neurology, Maastricht University Medical Center, Cardiovascular Research Institute, Maastricht, The Netherlands.
H SchenckDepartment of Neurology, Maastricht University Medical Center, Cardiovascular Research Institute, Maastricht, The Netherlands.
W A MoojenDepartment of Neurosurgery, Haaglanden Medical Center, The Hague, The Netherlands.
M H den HertogDepartment of Neurology, Isala Hospital, Zwolle, The Netherlands.
D NandaDepartment of Neurosurgery, Isala Hospital, Zwolle, The Netherlands.
A R E PotgieserDepartment of Neurosurgery, Medisch Spectrum Twente, Enschede, The Netherlands.
B A CoertAmsterdam UMC, Department of Neurosurgery, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
W I M VerhagenDepartment of Neurology, Haga Teaching Hospital, The Hague, The Netherlands.
R H M A BartelsDepartment of Neurosurgery, Radboud University Medical Center, PO Box 9101, Nijmegen, 6500 HB, The Netherlands.
P J van der WeesIQ healthcare and Department of Rehabilitation, Radboud University Medical Center, Radboud Institute of Health Sciences, Nijmegen, The Netherlands.
D VerbaanAmsterdam UMC, Department of Neurosurgery, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
H D BoogaartsDepartment of Neurosurgery, Radboud University Medical Center, PO Box 9101, Nijmegen, 6500 HB, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe modified Rankin Scale (mRS), a clinician-reported outcome measure of global disability, has never been validated in patients with aneurysmal subarachnoid hemorrhage (aSAH). The aims of this study are to assess: (1) convergent validity of the mRS; (2) responsiveness of the mRS; and (3) the distribution of mRS scores across patient-reported outcome measures (PROMs).

methodsThis is a prospective randomized multicenter study. The mRS was scored by a physician for all patients, and subsequently by structured interview for half of the patients and by self-assessment for the other half. All patients completed EuroQoL 5D-5L, RAND-36, Stroke Specific Quality of Life scale (SS-QoL) and Global Perceived Effect (GPE) questionnaires. Convergent validity and responsiveness were assessed by testing hypotheses.

resultsIn total, 149 patients with aSAH were included for analysis. The correlation of the mRS with EQ-5D-5L was r = - 0.546, while with RAND-36 physical and mental component scores the correlation was r = - 0.439and r = - 0.574 respectively, and with SS-QoL it was r = - 0.671. Three out of four hypotheses for convergent validity were met. The mRS assessed through structured interviews was more highly correlated with the mental component score than with the physical component score of RAND-36. Improvement in terms of GPE was indicated by 83% of patients; the mean change score of these patients on the mRS was - 0.08 (SD 0.915). None of the hypotheses for responsiveness were met.

conclusionThe results show that the mRS generally correlates with other instruments, as expected, but it lacks responsiveness. A structured interview of the mRS is best for detecting disabling neuropsychological complaints. REGISTRATION: URL: https://trialsearch.who.int ; Unique identifier: NL7859, Date of first administration: 08-07-2019.

Indexed as

StrokeSubarachnoid HemorrhageHumansProspective StudiesQuality of LifeSurveys and QuestionnairesConvergent validityModified Rankin ScaleResponsivenessSubarachnoid hemorrhage

Identifiers

PMID38216872
PMCPMC10785372

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.