Evidence map›Paper›PMID 38216854›Full record

ReviewFrontiers of medicine2024

Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair.

Tianjing Sun, Mo Li, Qi Liu, Anyong Yu, Kun Cheng, Jianxing Ma, Sean Murphy, Patrick Michael McNutt, Yuanyuan Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Exploring Exosomes for Pediatric Ischemic Auricular Flap Repair.Plastic and reconstructive surgery. Global open · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianjing Sun *Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China.
Mo Li *Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China.
Qi LiuDepartment of Nephrology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China. liuqi1964@hotmail.com.
Anyong YuDepartment of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China. anyongyu@163.com.
Kun ChengDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, 64108, USA.
Jianxing MaDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Sean MurphyWake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA.
Patrick Michael McNuttWake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA.
Yuanyuan ZhangWake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA. yzhang@wakehealth.edu.

Funding

Toxic Mechanisms of Vesicating Chemicals in the EyeR01EY034139 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNUTT, PATRICK MICHAEL · 2022 to 2024
$1.4M
3D Culture Systems Of Urine-Derived Stem Cell For NTRI-Induced Mitotoxicity AssessmentR21AI152832 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2020 to 2021
$426k
Silk Fibers-Assisted 3D System for Large-Scale Culture of Human Urine-Derived Stem Cells Suitable for Late Mitotoxicity TestingR03AI165170 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2021 to 2022
$155k
NEI NIH HHS R01 EY034139NIAID NIH HHS R03 AI165170NIAID NIH HHS R21 AI152832
6 · The paper itself

Abstract

Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond. Exosomes, small extracellular vesicles secreted by various stem cells, have emerged as potent mediators of intercellular communication and tissue repair. One advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy, such as immune rejection or stem cells differentiating into unwanted cell types. However, further research is necessary to optimize exosome therapy, not only in the areas of exosome isolation, characterization, and engineering, but also in determining the optimal dose, timing, administration, and frequency of exosome therapy. Thus, optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer, ischemia, or inflammation. This review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.

Indexed as

ExosomesSkinWound HealingAnimalsHumansexosomesskinstem cellstherapeutic impactwound healing

Identifiers

PMID38216854
PMCPMC11283324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.