Evidence map›Paper›PMID 38216687›Full record

ArticleScientific reports2024

Comparing deep learning and handcrafted radiomics to predict chemoradiotherapy response for locally advanced cervical cancer using pretreatment MRI.

Sungmoon Jeong, Hosang Yu, Shin-Hyung Park, Dongwon Woo, Seoung-Jun Lee, Gun Oh Chong, Hyung Soo Han, Jae-Chul Kim

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Artificial Intelligence in Obstetric and Gynecological MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sungmoon Jeong *Department of Medical Informatics, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Hosang Yu *Research Center for Artificial Intelligence in Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.
Shin-Hyung ParkDepartment of Radiation Oncology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. shinhyungpark@knu.ac.kr.
Dongwon WooResearch Center for Artificial Intelligence in Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.
Seoung-Jun LeeDepartment of Radiation Oncology, Kyungpook National University Hospital, Daegu, Republic of Korea.
Gun Oh ChongDepartment of Gynecology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Hyung Soo HanClinical Omics Research Center, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jae-Chul KimDepartment of Radiation Oncology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Funding

National Research Foundation of Korea (NRF) 2019R1G1A1089358National Research Foundation of Korea (NRF) 2021R1I1A3048826
6 · The paper itself

Abstract

Concurrent chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical cancer (LACC), but its responsiveness varies among patients. A reliable tool for predicting CRT responses is necessary for personalized cancer treatment. In this study, we constructed prediction models using handcrafted radiomics (HCR) and deep learning radiomics (DLR) based on pretreatment MRI data to predict CRT response in LACC. Furthermore, we investigated the potential improvement in prediction performance by incorporating clinical factors. A total of 252 LACC patients undergoing curative chemoradiotherapy are included. The patients are randomly divided into two independent groups for the training (167 patients) and test datasets (85 patients). Contrast-enhanced T1- and T2-weighted MR scans are obtained. For HCR analysis, 1890 imaging features are extracted and a support vector machine classifier with a five-fold cross-validation is trained on training dataset to predict CRT response and subsequently validated on test dataset. For DLR analysis, a 3-dimensional convolutional neural network was trained on training dataset and validated on test dataset. In conclusion, both HCR and DLR models could predict CRT responses in patients with LACC. The integration of clinical factors into radiomics prediction models tended to improve performance in HCR analysis. Our findings may contribute to the development of personalized treatment strategies for LACC patients.

Indexed as

Deep LearningUterine Cervical NeoplasmsChemoradiotherapyFemaleHumansMagnetic Resonance ImagingRadiomicsRetrospective Studies

Identifiers

PMID38216687
PMCPMC10786874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.