Evidence map›Paper›PMID 38216677›Full record

SynthesisJournal of perinatology : official journal of the California Perinatal Association2024

Peri-extubation settings in preterm neonates: a systematic review and meta-analysis.

Yogesha K Nagaraj, Said Al Balushi, Courtney Robb, Nikhil Uppal, Sourabh Dutta, Amit Mukerji

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Weight-adjusted rapid shallow breathing index during spontaneous breathing trial in mechanically ventilated preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. [Risk factors and prognosis of first extubation failure in neonates undergoing invasive mechanical ventilation].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yogesha K NagarajDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Said Al BalushiDepartment of Pediatrics, Suhar Hospital, Suhar, Oman.
Courtney RobbFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0009-0004-0269-7523
Nikhil UppalFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Sourabh DuttaDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.ORCID 0000-0002-5595-8289
Amit MukerjiDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada. mukerji@mcmaster.ca.ORCID 0000-0003-2609-9240

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically review: 1) peri-extubation settings; and 2) association between peri-extubation settings and outcomes in preterm neonates. STUDY

designIn this systematic review, studies were eligible if they reported patient-data on peri-extubation settings (objective 1) and/or evaluated peri-extubation levels in relation to clinical outcomes (objective 2). Data were meta-analyzed when appropriate using random-effects model.

resultsOf 9681 titles, 376 full-texts were reviewed and 101 included. The pooled means of peri-extubation settings were summarized. For objective 2, three experimental studies were identified comparing post-extubation CPAP levels. Meta-analyses revealed lower odds for treatment failure [pooled OR 0.46 (95% CI 0.27-0.76); 3 studies, 255 participants] but not for re-intubation [pooled OR 0.66 (0.22-1.97); 3 studies, 255 participants] with higher vs. lower CPAP.

conclusionsSummary of peri-extubation settings may guide clinicians in their own practices. Higher CPAP levels may reduce extubation failure, but more data on peri-extubation settings that optimize outcomes are needed.

Indexed as

Airway ExtubationContinuous Positive Airway PressureInfant, PrematureHumansInfant, NewbornRespiratory Distress Syndrome, NewbornVentilator Weaning

Identifiers

PMID38216677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.