Evidence map›Paper›PMID 38216585›Full record

ArticleNature communications2024

Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone.

Xiaoliang Ba, Yingyi Guo, Robert A Moran, Emma L Doughty, Baomo Liu, Likang Yao, Jiahui Li, Nanhao He, Siquan Shen, Yang Li and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Global spread of carbapenem-resistantOne health (Amsterdam, Netherlands) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. TheMicrobial genomics · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Cross-species transmission ofFrontiers in cellular and infection microbiology · 2026
    Review
  17. Article
  18. The emergence of highly resistant and hypervirulentEmerging microbes & infections · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaoliang Ba *Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-3882-3585
Yingyi Guo *State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID 0000-0001-9112-687X
Robert A MoranInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
Emma L DoughtyInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
Baomo LiuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Likang YaoState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jiahui LiState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Nanhao HeState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Siquan ShenInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Yang LiDepartment of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Willem van SchaikInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.ORCID 0000-0001-5832-0988
Alan McNallyInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.ORCID 0000-0002-3099-630X
Mark A HolmesDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. mah1@cam.ac.uk.ORCID 0000-0002-5454-1625
Chao ZhuoState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. chaosheep@sina.com.ORCID 0000-0003-2318-3236

Funding

Medical Research Council MR/S013660/1
6 · The paper itself

Abstract

Carbapenem-resistant Escherichia coli (CREC) ST410 has recently emerged as a major global health problem. Here, we report a shift in CREC prevalence in Chinese hospitals between 2017 and 2021 with ST410 becoming the most commonly isolated sequence type. Genomic analysis identifies a hypervirulent CREC ST410 clone, B5/H24RxC, which caused two separate outbreaks in a children's hospital. It may have emerged from the previously characterised B4/H24RxC in 2006 and has been isolated in ten other countries from 2015 to 2021. Compared with B4/H24RxC, B5/H24RxC lacks the bla

Indexed as

Carbapenem-Resistant EnterobacteriaceaeEscherichia coli InfectionsAnti-Bacterial Agentsbeta-LactamasesCarbapenemsChildClone CellsEscherichia coliHumansMicrobial Sensitivity TestsAnti-Bacterial Agentsbeta-LactamasesCarbapenems

Identifiers

PMID38216585
PMCPMC10786849

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.