Evidence map›Paper›PMID 38216566›Full record

Trial reportNature communications2024

A randomized trial looking at planning prompts to reduce opioid prescribing.

Jason N Doctor, Marcella A Kelley, Noah J Goldstein, Jonathan Lucas, Tara Knight, Emily P Stewart

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03856593 (Comparative Effectiveness of Two Letters to Encourage Judicious Prescribing of Opioids), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03856593 nacompletednot on this map

Comparative Effectiveness of Two Letters to Encourage Judicious Prescribing of Opioids: A County-wide Project in Los Angeles

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2019 to 2021Enrolled541ConditionsSubstance-Related DisordersArmsStandard letter, Comparator letter
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jason N DoctorSol Price School of Public Policy, University of Southern California, Los Angeles, CA, 90089, USA. jdoctor@usc.edu.ORCID 0000-0003-3661-8745
Marcella A KelleyEdwards Lifesciences, Irvine, CA, 92614, USA.
Noah J GoldsteinUCLA Anderson School of Management, UCLA Geffen School of Medicine, Los Angeles, CA, 90095, USA.
Jonathan LucasDepartment of Medical Examiner-Coroner, County of Los Angeles, Los Angeles, CA, USA.
Tara KnightSol Price School of Public Policy, University of Southern California, Los Angeles, CA, 90089, USA.
Emily P StewartSol Price School of Public Policy, University of Southern California, Los Angeles, CA, 90089, USA.
University of Southern California · USAnderson University - South Carolina · USEdwards Lifesciences (United States) · US

Funding

USC-Yale Roybal Center for Behavioral Interventions in AgingP30AG024968 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JASON N. DOCTOR, Daniella Meeker · 2004 to 2026
$14.7M
NIA NIH HHS P30 AG024968
6 · The paper itself

Abstract

Prior work has demonstrated that personalized letters are effective at reducing opioid and benzodiazepine prescribing, but it is unclear whether If/when-then planning prompts would enhance this effect. We conducted a decedent-clustered trial which randomized 541 clinicians in Los Angeles County to receive a standard (n = 284), or comparator (n = 257) version of a letter with If/when-then prompts. We found a significant 12.85% (6.83%, 18.49%) and 8.32% (2.34%, 13.93%) decrease in the primary outcomes morphine (MME) and diazepam milligram equivalents (DME), respectively. This study confirms the benefit of planning prompts, and repeat letter exposure among clinicians with poor patient outcomes. Limitations include lack of generalizability and small sample size. Clinicaltrials.gov registration: NCT03856593.

Indexed as

Analgesics, OpioidPractice Patterns, Physicians'DiazepamHumansMorphineAnalgesics, OpioidDiazepamMorphine

Identifiers

PMID38216566
PMCPMC10786898
OpenAlexW4390789457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.