Evidence map›Paper›PMID 38216434›Full record

Trial reportChinese journal of traumatology = Zhonghua chuang shang za zhi2024

Clinical efficacy of the topical application of tranexamic acid in tendon release in the hand: A randomized controlled trial.

Hao Liu, Jun Liu, Yong-Wei Wu, Ming Zhou, Yong-Jun Rui

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hao LiuSuzhou Medical College of Soochow University, Suzhou, 215000, Jiangsu province, China; Department of Traumatic Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214000, Jiangsu province, China.
Jun LiuDepartment of Traumatic Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214000, Jiangsu province, China.
Yong-Wei WuDepartment of Traumatic Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214000, Jiangsu province, China.
Ming ZhouSuzhou Medical College of Soochow University, Suzhou, 215000, Jiangsu province, China; Department of Traumatic Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214000, Jiangsu province, China.
Yong-Jun RuiDepartment of Traumatic Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214000, Jiangsu province, China. Electronic address: wxjyryj@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study the clinical effectiveness of the topical application of tranexamic acid in hand tendon release.

methodsThis was a randomized controlled trial conducted after receiving approval from the local ethics committee according to guidelines from the Helsinki Declaration. Eighty patients who underwent hand tendon release operation in our hospital from January 2021 to December 2022 were included and randomly divided into 2 groups. Patients in the tranexamic acid group (40 cases) received intraoperative topical application of 2 g of tranexamic acid after tendon release, while patients in the conventional group (40 cases) did not receive topical application of tranexamic acid during operation. The operation time, perioperative hemoglobin changes, total blood loss, incidence of early postoperative complications, and total active movement (TAM) before surgery and 6 months after surgery were compared between the 2 groups. The continuous variable which follows normal distribution expressed by mean ± SD and used t-test to compare between groups. Meanwhile, categorical variables were used by Chi-square test, and a p < 0.05 indicated that the differences were statistically significant.

resultsBoth groups were followed up for 7 - 18 months, with a mean of 10.3 months. Postoperative decrease in hemoglobin was significantly less in the tranexamic acid group than in the conventional group (t = 7.611, p < 0.001). The total blood loss in the tranexamic acid group (74.33 ± 20.50) mL was less than that in the conventional group (83.05 ± 17.73) mL, and the difference was statistically significant (p < 0.05). Both groups showed improvement in thumb/finger flexion and extension range of motion after surgery, and the TAM improved compared with those before surgery, and the difference was statistically significant (p < 0.001). The TAM improved more significantly in the tranexamic acid group (87.68° ± 10.44°) than in the conventional group (80.47° ± 10.93°) at 6 months after surgery, with a statistically significant difference (t = 3.013, p < 0.001). There was no significant difference in operation time and incidence of early postoperative complications between the 2 groups (p = 0.798, 0.499, respectively).

conclusionThe topical application of tranexamic acid during hand tendon release can significantly reduce postoperative bleeding and improve surgical efficacy, which is worth promoting.

Indexed as

Administration, TopicalAntifibrinolytic AgentsTranexamic AcidAdultBlood Loss, SurgicalFemaleHandHumansMaleMiddle AgedOperative TimePostoperative ComplicationsTendon InjuriesTreatment OutcomeAntifibrinolytic AgentsTranexamic AcidTendon adhesionTendon releaseTotal active movementTranexamic acid

Identifiers

PMID38216434
PMCPMC11138941

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.