ArticleCell genomics2024
Combinatorial expression motifs in signaling pathways.
Article in Cell genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
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- Spatial Modeling of Tissues for Morphogenic Field Analysis.bioRxiv : the preprint server for biology · 2025Article
- Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Engineering development: From the repressilator and toggle switch to synthetic developmental biology.Developmental biology · 2025Review
- The Notch pathway: A guardian of cell fate during neurogenesis.Current opinion in cell biology · 2025Review
- Pattern recognition in living cells through the lens of machine learning.Open biology · 2025Review
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- Covalent Dynamic DNA Networks to Translate Multiple Inputs into Programmable Outputs.Journal of the American Chemical Society · 2025Article
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- Linking signal input, cell state, and spatial context to inflammatory responses.Current opinion in immunology · 2024Review
- Principles of Computation by Competitive Protein Dimerization Networks.bioRxiv : the preprint server for biology · 2024Article
- The computational capabilities of many-to-many protein interaction networks.Cell systems · 2023Review
- Lineage motifs: developmental modules for control of cell type proportions.bioRxiv : the preprint server for biology · 2023Article
- New aspects of TGF-β superfamily signaling in development and disease (2022 FASEB meeting review).Faculty reviews · 2022Review
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3 authors at 1 institution in 1 country.
Funding
Abstract
In animal cells, molecular pathways often comprise families of variant components, such as ligands or receptors. These pathway components are differentially expressed by different cell types, potentially tailoring pathway function to cell context. However, it has remained unclear how pathway expression profiles are distributed across cell types and whether similar profiles can occur in dissimilar cell types. Here, using single-cell gene expression datasets, we identified pathway expression motifs, defined as recurrent expression profiles that are broadly distributed across diverse cell types. Motifs appeared in core pathways, including TGF-β, Notch, Wnt, and the SRSF splice factors, and involved combinatorial co-expression of multiple components. Motif usage was weakly correlated between pathways in adult cell types and during dynamic developmental transitions. Together, these results suggest a mosaic view of cell type organization, in which different cell types operate many of the same pathways in distinct modes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.