ArticleJournal of the Academy of Nutrition and Dietetics2024
Diet Quality and Epigenetic Aging in the Women's Health Initiative.
Article in Journal of the Academy of Nutrition and Dietetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Epigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations.GeroScience · 2026Trial
- Dietary pattern and epigenetic aging: a longitudinal twin study.GeroScience · 2026Article
- Responsiveness of epigenetic aging biomarkers to longevity interventions in humans.Nature medicine · 2026Article
- Adolescent disordered eating and epigenetic age acceleration.Molecular psychiatry · 2026Article
- The role of Mediterranean diet adherence, smoking and their interactions in epigenetic age acceleration: A cross-sectional analysis of the Airwave cohort.The journal of nutrition, health & aging · 2026Article
- Diet Quality, Physical Activity, and Epigenetic Aging in the Finnish Working-Age Population.The Journal of nutrition · 2026Article
- Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study.BMC medicine · 2026Article
- Epigenetic ageing and the risk of Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Lower diet quality accelerates DNA methylation-based age.GeroScience · 2026Article
- Dietary pattern modifies associations between dietary factors and pace of epigenetic aging.Frontiers in nutrition · 2026Article
- Article
- Dietary fatty acids and epigenetic aging in US adults: results from the National Health and Nutrition Examination Survey.npj aging · 2025Article
- FFQ-NutriForHer: Reproducibility and Validity of a Semi-Quantitative Food Frequency Questionnaire for Young and Older Women.Nutrients · 2025Article
- Western Diet and Cognitive Decline: A Hungarian Perspective-Implications for the Design of the Semmelweis Study.Nutrients · 2025Review
- Slower Pace of Epigenetic Aging and Lower Inflammatory Indicators in Females Following a Nutrient-Dense, Plant-Rich Diet Than Those in Females Following the Standard American Diet.Current developments in nutrition · 2024Article
- Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study.Annals of neurology · 2024Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundHigher diet quality scores are associated with a lower risk for many chronic diseases and all-cause mortality; however, it is unclear if diet quality is associated with aging biology.
objectiveThis study aimed to examine the association between diet quality and a measure of biological aging known as epigenetic aging.
designA cross-sectional data analysis was used to examine the association between three diet quality scores based on self-reported food frequency questionnaire data and five measures of epigenetic aging based on DNA methylation (DNAm) data from peripheral blood. PARTICIPANTS/
settingThis study included 4,500 postmenopausal women recruited from multiple sites across the United States (1993-98), aged 50 to 79 years, with food frequency questionnaire and DNAm data available from the Women's Health Initiative baseline visit.
main outcome measuresFive established epigenetic aging measures were generated from HumanMethylation450 Beadchip DNAm data, including AgeAccelHannum, AgeAccelHorvath, AgeAccelPheno, AgeAccelGrim, and DunedinPACE. STATISTICAL ANALYSES PERFORMED: Linear mixed models were used to test for associations between three diet quality scores (Healthy Eating Index, Dietary Approaches to Stop Hypertension, and alternate Mediterranean diet scores) and epigenetic aging measures, adjusted for age, race and ethnicity, education, tobacco smoking, physical activity, Women's Health Initiative substudy from which DNAm data were obtained, and DNAm-based estimates of leukocyte proportions.
resultsHealthy Eating Index, Dietary Approaches to Stop Hypertension, and alternate Mediterranean diet scores were all inversely associated with AgeAccelPheno, AgeAccelGrim, and DunedinPACE (P < 0.05), with the largest effects with DunedinPACE. A one standard deviation increment in diet quality scores was associated with a decrement (β ± SE) in DunedinPACE z score of -0.097 ± 0.014 (P = 9.70 x 10
conclusionsIn postmenopausal women, diet quality scores were inversely associated with DNAm-based measures of biological aging, particularly DunedinPACE.
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