Evidence map›Paper›PMID 38215886›Full record

Trial reportThe American journal of clinical nutrition2024

Acute ingestion of a ketone monoester, whey protein, or their co-ingestion in the overnight postabsorptive state elicit a similar stimulation of myofibrillar protein synthesis rates in young males: a double-blind randomized trial.

Sarkis J Hannaian, Jamie Lov, Stephanie E Hawley, Manon Dargegen, Divine Malenda, Ari Gritsas, Gilles Gouspillou, José A Morais, Tyler A Churchward-Venne

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04565444 (The Effects of Acute Nutritional Ketosis on Myofibrillar Protein Synthesis in Young Men), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04565444 nacompletednot on this map

The Effects of Acute Nutritional Ketosis on Myofibrillar Protein Synthesis in Young Men

TypeinterventionalSponsorMcGill UniversityRan2020 to 2021Enrolled36ConditionsKetosis, Regulation of Muscle Protein SynthesisArmsKetone, Ketone + Protein, Protein
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sarkis J HannaianDepartment of Kinesiology and Physical Education, McGill University, Montréal, Quebec, Canada; Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada.
Jamie LovDepartment of Kinesiology and Physical Education, McGill University, Montréal, Quebec, Canada.
Stephanie E HawleyDepartment of Kinesiology and Physical Education, McGill University, Montréal, Quebec, Canada.
Manon DargegenResearch Institute of the McGill University Health Centre, Montréal, Quebec, Canada.
Divine MalendaDepartment of Kinesiology and Physical Education, McGill University, Montréal, Quebec, Canada.
Ari GritsasResearch Institute of the McGill University Health Centre, Montréal, Quebec, Canada.
Gilles GouspillouDépartement des Sciences de l'activité Physique, Faculté des Sciences, UQAM, Montréal, Quebec, Canada.
José A MoraisDepartment of Kinesiology and Physical Education, McGill University, Montréal, Quebec, Canada; Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada; Division of Geriatric Medicine, McGill University, Montréal, Quebec, Canada.
Tyler A Churchward-VenneDepartment of Kinesiology and Physical Education, McGill University, Montréal, Quebec, Canada; Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada; Division of Geriatric Medicine, McGill University, Montréal, Quebec, Canada. Electronic address: tyler.churchward-venne@mcgill.ca.
McGill University Health Centre · CAMcGill University · CAUniversité du Québec à Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKetone bodies may have anabolic effects in skeletal muscle via their capacity to stimulate protein synthesis. Whether orally ingested exogenous ketones can stimulate postprandial myofibrillar protein synthesis (MyoPS) rates with and without dietary protein co-ingestion is unknown.

objectivesThis study aimed to evaluate the effects of ketone monoester intake and elevated blood β-hydroxybutyrate (β-OHB) concentration, with and without dietary protein co-ingestion, on postprandial MyoPS rates and mechanistic target of rapamycin complex 1 (mTORC1) pathway signaling.

methodsIn a randomized, double-blind, parallel group design, 36 recreationally active healthy young males (age: 24.2 ± 4.1 y; body fat: 20.9% ± 5.8%; body mass index: 23.4 ± 2 kg/m

resultsCapillary blood β-OHB concentration increased similarly during postprandial conditions in KET and KET+PRO, with both being greater than PRO from 30 to 180 min (treatment × time interaction: P < 0.001). Postprandial plasma leucine and essential amino acid (EAA) incremental area under the curve (iAUC) over 300 min was greater (treatment: both P < 0.001) in KET+PRO compared with PRO and KET. KET, PRO, and KET+PRO stimulated postprandial MyoPS rates (0-300 min) higher than basal conditions [absolute change: 0.020%/h; (95% CI: 0.013, 0.027%/h), 0.014%/h (95% CI: 0.009, 0.019%/h), 0.019%/h (95% CI: 0.014, 0.024%/h), respectively (time: P < 0.001)], with no difference between treatments (treatment: P = 0.383) or treatment × time interaction (interaction: P = 0.245). mTORC1 pathway signaling responses did not differ between treatments (all P > 0.05).

conclusionsAcute oral intake of a ketone monoester, 10 g whey protein, or their co-ingestion in the overnight postabsorptive state elicit a similar stimulation of postprandial MyoPS rates in healthy young males. This trial was registered at clinicaltrials.gov as NCT04565444 (https://clinicaltrials.gov/study/NCT04565444).

Indexed as

Dietary ProteinsKetonesAdultDouble-Blind MethodEatingHumansMaleMechanistic Target of Rapamycin Complex 1Muscle, SkeletalPostprandial PeriodWhey ProteinsYoung AdultDietary ProteinsKetonesMechanistic Target of Rapamycin Complex 1Whey Proteinsamino acidsexogenous ketosisketone bodiesmyofibrillar protein synthesisskeletal musclewhey proteinyoung malesβ-hydroxybutyrate

Identifiers

PMID38215886
PMCPMC10972741
OpenAlexW4390746708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.