Evidence map›Paper›PMID 38215761›Full record

ReviewCell reports methods2024

Electome network factors: Capturing emotional brain networks related to health and disease.

Kathryn Walder-Christensen, Karim Abdelaal, Hunter Klein, Gwenaëlle E Thomas, Neil M Gallagher, Austin Talbot, Elise Adamson, Ashleigh Rawls, Dalton Hughes, Stephen D Mague and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Cell reports methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Generative Principal Component Regression via Variational Inference.IEEE transactions on signal processing : a publication of the IEEE Signal Processing Society · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Making sense of feelings.Neuroscience of consciousness · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kathryn Walder-ChristensenDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Karim AbdelaalDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Hunter KleinDepartment of Electrical and Computer Engineering, Duke University, Durham, NC 27710, USA.
Gwenaëlle E ThomasDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Neil M GallagherDepartment of Psychiatry, Weill Cornell Medical Center, New York City, NY 10065, USA.
Austin TalbotHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Elise AdamsonHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.
Ashleigh RawlsDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Dalton HughesDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Stephen D MagueDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Kafui DzirasaDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. Electronic address: kafui.dzirasa@duke.edu.
David E CarlsonDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA; Department of Civil and Environmental Engineering, Duke University, Durham, NC 27710, USA. Electronic address: david.carlson@duke.edu.
Howard Hughes Medical Institute · USDuke University · USCornell University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Therapeutic development for mental disorders has been slow despite the high worldwide prevalence of illness. Unfortunately, cellular and circuit insights into disease etiology have largely failed to generalize across individuals that carry the same diagnosis, reflecting an unmet need to identify convergent mechanisms that would facilitate optimal treatment. Here, we discuss how mesoscale networks can encode affect and other cognitive processes. These networks can be discovered through electrical functional connectome (electome) analysis, a method built upon explainable machine learning models for analyzing and interpreting mesoscale brain-wide signals in a behavioral context. We also outline best practices for identifying these generalizable, interpretable, and biologically relevant networks. Looking forward, translational electome analysis can span species and various moods, cognitive processes, or other brain states, supporting translational medicine. Thus, we argue that electome analysis provides potential translational biomarkers for developing next-generation therapeutics that exhibit high efficacy across heterogeneous disorders.

Indexed as

ConnectomeMental DisordersBrainHumansMachine LearningMagnetic Resonance ImagingCP: Neuroscience

Identifiers

PMID38215761
PMCPMC10832286
OpenAlexW4390739416

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.