Evidence map›Paper›PMID 38215360›Full record

ArticleAdvanced healthcare materials2024

Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment.

Nick A Alden, Tyus J Yeingst, Hanna M Pfeiffer, Nazmiye Celik, Julien H Arrizabalaga, Angelica M Helton, Yiming Liu, Douglas B Stairs, Adam B Glick, Neerav Goyal and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Nick A AldenDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.ORCID 0000-0003-1380-131X
Tyus J YeingstDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Hanna M PfeifferDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Nazmiye CelikThe Huck Institute of the Life Sciences, Millennium Science Complex, The Pennsylvania State University, University Park, PA, 16802, USA.
Julien H ArrizabalagaDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Angelica M HeltonDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Yiming LiuDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Douglas B StairsDepartment of Pathology, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.
Adam B GlickThe Huck Institute of the Life Sciences, Millennium Science Complex, The Pennsylvania State University, University Park, PA, 16802, USA.
Neerav GoyalDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.
Daniel J HayesDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.ORCID 0000-0001-9499-4111
Pennsylvania State University · US

Funding

Spatiotemporal Modulation of Osteogenesis in a 3-D Stromal/Stem Cell ModelR01DE024790 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI HAYES, DANIEL J. · 2015 to 2019
$1.7M
Ultrasound responsive hydrogels for stimulated combinatorial drug deliveryR21DE032155 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI HAYES, DANIEL J. · 2023 to 2023
$361k
NIDCR NIH HHS R01 DE024790NIDCR NIH HHS R21 DE032155NIDCR NIH HHS RDE024790A
6 · The paper itself

Abstract

Current nucleic acid delivery methods have not achieved efficient, non-toxic delivery of miRNAs with tumor-specific selectivity. In this study, a new delivery system based on light-inducible gold-silver-gold, core-shell-shell (CSS) nanoparticles is presented. This system delivers small nucleic acid therapeutics with precise spatiotemporal control, demonstrating the potential for achieving tumor-specific selectivity and efficient delivery of miRNA mimics. The light-inducible particles leverage the photothermal heating of metal nanoparticles due to the local surface plasmonic resonance for controlled chemical cleavage and release of the miRNA mimic payload. The CSS morphology and composition result in a plasmonic resonance within the near-infrared (NIR) region of the light spectrum. Through this method, exogenous miR-34a-5p mimics are effectively delivered to human squamous cell carcinoma TE10 cells, leading to apoptosis induction without adverse effects on untransformed keratinocytes in vitro. The CSS nanoparticle delivery system is tested in vivo in Foxn1nu athymic nude mice with bilateral human esophageal TE10 cancer cells xenografts. These experiments reveal that this CSS nanoparticle conjugates, when systemically administered, followed by 850 nm light emitting diode irradiation at the tumor site, 6 h post-injection, produce a significant and sustained reduction in tumor volume, exceeding 87% in less than 72 h.

Indexed as

Esophageal NeoplasmsMetal NanoparticlesMicroRNAsNanoparticlesAnimalsCell Line, TumorGoldHumansMiceMice, NudeGoldMicroRNAsDiels–Alderesophageal cancermiR‐34anear‐infraredplasmonic nanoparticles

Identifiers

PMID38215360
PMCPMC11032112
OpenAlexW4390787679

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.