Observational studyThe Journal of clinical endocrinology and metabolism2024
Phase Angle of Bioelectrical Impedance Analysis as an Indicator for Diabetic Polyneuropathy in Type 2 Diabetes Mellitus.
Observational study in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Observational
- Association of the phase angle with type 2 diabetes and related traits: results from two prospective KORA studies.Nutrition & diabetes · 2026Article
- Relationship between low phase angle and impaired healing of diabetic foot ulcer: a retrospective cohort study.Nutrition & metabolism · 2026Article
- Integrated analysis of neuromuscular dysfunction and metabolic dysregulation in diabetic peripheral neuropathy: associations with digital deformities and clinical risk stratification in a case-control study.Frontiers in physiology · 2026Article
- Cohort profile of the Heidelberg study on diabetes and complications HEIST-DiC.Scientific reports · 2025Article
- Bioelectrical Impedance Profiling to Estimate Neuropathic and Vascular Risk in Patients with Type 2 Diabetes Mellitus.Diagnostics (Basel, Switzerland) · 2025Article
- Phase Angle Evaluated by a Bioimpedance Analysis Is Closely Related to Diabetic Nephropathy and Peripheral Neuropathy in Patients with Type 2 Diabetes.JMA journal · 2025Article
- Exploring the significance of phase angle in diabetes management: a narrative review.Diabetology international · 2025Review
- Stronger associations of the phase angle than the TyG index with micro- and macrovascular complications in patients with type 2 diabetes.Lipids in health and disease · 2025Article
- Plantar cutaneous sensation is independently associated with postural balance and lower limb motor function in older adults: the Shizuoka study.European geriatric medicine · 2025Article
- Phase Angle of Bioelectrical Impedance Analysis as an Indicator for Diabetic Polyneuropathy in Type 2 Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2024Observational
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
contextDue to the heterogenous clinical symptoms and deficits, the diagnosis of diabetic polyneuropathy (DPN) is still difficult in clinical routines, leading to increased morbidity and mortality.
objectiveWe studied the correlation of phase angle (PhA) of bioelectrical impedance analysis (BIA) with clinical, laboratory, and physical markers of DPN to evaluate PhA as a possible diagnostic method for DPN. MATERIALS AND
methodsIn this cross-sectional observational study as part of the Heidelberg Study on Diabetes and Complications, we examined 104 healthy individuals and 205 patients with type 2 diabetes mellitus (T2D), among which 63 had DPN. The PhA was calculated from multifrequency BIA. Nerve conduction studies, quantitative sensory testing (QST) and diffusion-weighted magnetic resonance neurography to determine fractional anisotropy (FA) reflecting peripheral nerve integrity were performed.
resultsT2D patients with DPN had lower PhA values (5.71 ± 0.10) compared to T2D patients without DPN (6.07 ± 0.08, P = .007, + 6.1%) and healthy controls (6.18 ± 0.08, P < .001, + 7.9%). Confounder-adjusted analyses showed correlations of the PhA with conduction velocities and amplitudes of the peroneal (β=.28; β=.31, P < .001) and tibial nerves (β=.28; β=.32, P < .001), Z-scores of QST (thermal detection β=.30, P < .05) and the FA (β=.60, P < .001). Receiver-operating characteristic analysis showed similar performance of PhA in comparison to the mentioned diagnostic methods.
conclusionThe study shows that PhA is, in comparison to other test systems used, at least an equally good and much easier to handle investigator-independent marker for detection of DPN.
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