Evidence map›Paper›PMID 38215053›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.

Pei-Chuan Ho, Wai Haung Yu, Boon Lead Tee, Wan-Ping Lee, Clara Li, Yian Gu, Jennifer S Yokoyama, Dolly Reyes-Dumeyer, Yun-Beom Choi, Hyun-Sik Yang and 72 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Observational
  2. Article
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  4. Cognitive impairment and p-tau217 are high in a vascular patient cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  9. Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

82 authors at 20 institutions in 4 countries.

Pei-Chuan HoPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Wai Haung YuBrain Health and Imaging Center and Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Boon Lead TeeMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Wan-Ping LeePenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Clara LiAlzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yian GuDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.
Jennifer S YokoyamaMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Dolly Reyes-DumeyerGertrude H. Sergievsky Center, Taub Institute of Aging Brain and Department of Neurology at Columbia University, New York, New York, USA.
Yun-Beom ChoiEnglewood Health, Englewood, New Jersey, USA.
Hyun-Sik YangCenter for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Badri N VardarajanGertrude H. Sergievsky Center, Taub Institute of Aging Brain and Department of Neurology at Columbia University, New York, New York, USA.
Marian TzuangDepartment of Community Health Systems, University of California San Francisco School of Nursing, San Francisco, California, USA.
Kevin LieuMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Anna LuAlzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Kelley M FaberDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Zoë D PotterDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Carolyn RevtaAlzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Maureen KirschPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jake McCallumGeriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Diana MeiMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Briana BoothPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Laura B CantwellPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Fangcong ChenDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.
Sephera ChouGeriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Dewi ClarkGeriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Michelle DengGeriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Ting Hei HongUniversity of Southern California, Los Angeles, California, USA.
Ling-Jen HwangStanford Alzheimer's Disease Research Center, Stanford, California, USA.
Lilly JiangUniversity of Southern California, Los Angeles, California, USA.
Yoonmee JooDepartment of Community Health Systems, University of California San Francisco School of Nursing, San Francisco, California, USA.
Younhee KangCollege of Nursing, Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Republic of Korea.
Ellen S KimDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Hoowon KimDepartment of Neurology, Chosun University Hospital, Dong-gu, Gwangju, Republic of Korea.
Kyungmin KimDepartment of Child Development and Family Studies, College of Human Ecology, Seoul National University, Jongno-gu, Seoul, Republic of Korea.
Amanda B KuzmaPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Eleanor LamGeriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Serggio C LanataMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Kunho LeeBiomedical Science, College of Natural Sciences, Chosun University, Gwanak-gu, Seoul, Republic of Korea.
Donghe LiDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.
Mingyao LiDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Xiang LiGeriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Chia-Lun LiuPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Collin LiuDepartment of Neurology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA.
Linghsi LiuAlzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jody-Lynn LupoAlzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Khai NguyenDepartment of Medicine, University of California at San Diego, La Jolla, California, USA.
Shannon E PfleugerDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
James QianMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Winnie QianGeriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Veronica RamirezStanford Alzheimer's Disease Research Center, Stanford, California, USA.
Kristen A RussDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Eun Hyun SeoPremedical Science, College of Medicine, Chosun University, Dong-gu, Gwangju, Republic of Korea.
Yeunjoo E SongDepartment of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Lu TianDepartment of Biomedical Data Science, Stanford University School of Medicine, Stanford, California, USA.
Mina TorresSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, California, USA.
Namkhue VoAlzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Ellen C WongDepartment of Neurology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA.
Yuan XieDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.
Eugene B YauDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Isabelle YiStanford Alzheimer's Disease Research Center, Stanford, California, USA.
Victoria YuDepartment of Ophthalmology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA.
Xiaoyi ZengAlzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Peter St George-HyslopTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Rhoda AuDepartment of Anatomy and Neurobiology, Slone Epidemiology Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Gerard D SchellenbergPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jeffrey L DageDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Rohit VarmaSouthern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, California, USA.
Ging-Yuek R HsiungDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Howard RosenMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Victor W HendersonDepartment of Epidemiology and Population Health, Stanford University, Stanford, California, USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Walter A KukullDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Guerry M PeavyDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Haeok LeeRory Meyers College of Nursing, New York University, New York, New York, USA.
Howard H FeldmanAlzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.
Richard MayeuxDepartment of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, Vagelos College of Physicians and Surgeons, New York, New York, USA.
Helena ChuiDepartment of Neurology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA.
Gyungah R JunDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.
Van M Ta ParkDepartment of Community Health Systems, University of California San Francisco School of Nursing, San Francisco, California, USA.
Tiffany W ChowPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Li-San WangPenn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3684-0031
University of California, San Francisco · USUniversity of Pennsylvania · USCentre for Addiction and Mental Health · CAUniversity of California San Diego · USUniversity of Southern California · USIndiana University School of MedicineUniversity of British Columbia · CABoston University · USColumbia University · USColumbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · USChosun University · KRPenn Presbyterian Medical Center · USUniversity of Toronto · CAAlector (United States) · USBroad Institute · USCase Western Reserve University · USChosun University Hospital · KREwha Womans University · KRNew York University · US

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
TBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ting Fang Alvin Ang · 2020 to 2026
$42.4M
Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · PI HELENA Chang CHUI, Gyungah Jun · 2023 to 2026
$39.4M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Serggio Carlo Lanata · 2019 to 2026
$36.9M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Steven Dyal Edland · 2019 to 2026
$34.9M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Andrew Franklin Teich · 2020 to 2026
$30.1M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0R01AG083926 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joshua Grill, Van My Ta Park · 2023 to 2026
$12.9M
Chinese American Eye StudyU10EY017337 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VARMA, ROHIT · 2009 to 2013
$10.2M
Chinese language versions of the National Alzheimer's Coordinating Center's Uniform Data Set version 4: a linguistic and cultural adaptation studyR01AG083840 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Clara Li, Boon Lead Tee · 2023 to 2026
$5.3M
Asian Cohort for Alzheimer's Disease (ACAD)R56AG069130 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CHUI, HELENA CHANG, JUN, GYUNGAH · 2020 to 2021
$4.9M
Alzheimer's Association AACSFD-22-972143Alzheimer's Association ALZ-NAN-22-928181NEI NIH HHS U10 EY017337NEI NIH HHS U10EY017337NIA NIH HHS K23 AG062750NIA NIH HHS K23AG062750NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P30AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG062588NIA NIH HHS R01 AG072562NIA NIH HHS R01 AG080469NIA NIH HHS R01AG080469NIA NIH HHS R01 AG083840NIA NIH HHS R01AG083840NIA NIH HHS R01 AG083926NIA NIH HHS R01AG083926NIA NIH HHS R03 AG061439NIA NIH HHS R21 AG068757NIA NIH HHS R21AG068757NIA NIH HHS R21 AG077649NIA NIH HHS R21AG077649NIA NIH HHS R24 AG063718NIA NIH HHS R24AG063718NIA NIH HHS R56 AG069130NIA NIH HHS R61 AG083582NIA NIH HHS R61AG083582NIA NIH HHS U19 AG068753NIA NIH HHS U19AG068753NIA NIH HHS U19 AG079774NIA NIH HHS U19AG079774NIA NIH HHS U24 AG021886NIA NIH HHS U24AG021886NIA NIH HHS UH2 AG083258NIA NIH HHS UH2AG083258
6 · The paper itself

Abstract

introductionClinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population.

methodsThe ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese.

resultsACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception. DISCUSSION: ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness. HIGHLIGHTS: The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.

Indexed as

Alzheimer DiseaseNorth American PeopleAsianCanadaHumansPilot ProjectsRisk FactorsAlzheimer's diseaseAsianbiosamplescommunity-based participatory researchdementiaenvironmentalgenetics

Identifiers

PMID38215053
PMCPMC10984480
OpenAlexW4390812544

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.