Evidence map›Paper›PMID 38214852›Full record

Observational studyJournal of endocrinological investigation2024

Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy.

M Arosio, V Sciannameo, A Contarino, P Berchialla, S Puglisi, A C Pesatori, E Ferrante, M Filopanti, R Pivonello, F Dassie and 17 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Myocardial Mechanics in Acromegaly: A Meta-Analysis of Echocardiographic Studies.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024
    Pooled it
  2. Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

M ArosioEndocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
V SciannameoStatistical Unit, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.
A ContarinoEndocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy. andrea.contarino@unimi.it.ORCID http://orcid.org/0000-0002-9300-8516
P BerchiallaStatistical Unit, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.
S PuglisiInternal Medicine, Department of Clinical and Biological Sciences, S. Luigi Hospital, University of Turin, Turin, Italy.
A C PesatoriEPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
E FerranteEndocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
M FilopantiEndocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
R PivonelloDivision of Endocrinology, Department of Clinical Medicine and Surgery, University Federico II Di Napoli, Naples, Italy.
F DassieInternal Medicine, Department of Medicine, DIMED, University of Padova, Padua, Italy.
V RochiraEndocrinology Unit, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
S CannavòDepartment of Human Pathology "G. Barresi", University of Messina, Messina, Italy.
E De MenisInternal Medicine 2-Endocrine-Metabolic Department, Treviso Hospital, Montebelluna, Treviso, Italy.
F PigliaruEndocrinology Unit, AOU Cagliari, Cagliari, Italy.
S GrottoliDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, AOU Città della Salute e della Scienza, Turin, Italy.
V CambriaDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, AOU Città della Salute e della Scienza, Turin, Italy.
M Faustini-FustiniIRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.
M MontiniAmbulatori di Endocrinologia, Humanitas Gavazzeni, Bergamo, Italy.
A PeriPituitary Diseases and Sodium Alterations Unit, Endocrinology, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", Careggi University Hospital, University of Florence, Florence, Italy.
F CeccatoDepartment of Medicine (DIMED), University of Padova, Padua, Italy.
E PuxedduDepartment of Medicine and Surgery, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy.
G BorrettaDivision of Endocrinology and Metabolism, Santa Croce and Carle Hospital, Cuneo, Italy.
M BondanelliSection of Endocrinology, Geriatrics and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
D FeroneEndocrinology Unit, Department of Internal Medicine and Medical Specialties (DI.M.I.), University of Genoa, Genoa, Italy.
A ColaoDivision of Endocrinology, Department of Clinical Medicine and Surgery, University Federico II Di Napoli, Naples, Italy.
M Terzolo *Internal Medicine, Department of Clinical and Biological Sciences, S. Luigi Hospital, University of Turin, Turin, Italy.
G Reimondo *Internal Medicine, Department of Clinical and Biological Sciences, S. Luigi Hospital, University of Turin, Turin, Italy.

Funding

Ministero della Salute NET-2018-12365454
6 · The paper itself

Abstract

objectiveThis study aimed to assess the long-term outcome of patients with acromegaly.

designThis is a multicenter, retrospective, observational study which extends the mean observation period of a previously reported cohort of Italian patients with acromegaly to 15 years of follow-up.

methodsOnly patients from the centers that provided information on the life status of at least 95% of their original cohorts were included. Life status information was collected either from clinical records or from the municipal registry offices. Standardized mortality ratios (SMRs) were computed comparing data with those of the general Italian population.

resultsA total of 811 patients were included. There were 153 deaths, with 90 expected and an SMR of 1.7 (95% CI 1.4-2.0, p < 0.001). Death occurred after a median of 15 (women) or 16 (men) years from the diagnosis, without gender differences. Mortality remained elevated in the patients with control of disease (SMR 1.3, 95% CI 1.1-1.6). In the multivariable analysis, only older age and high IGF1 concentrations at last available follow-up visit were predictors of mortality. The oncological causes of death outweighed the cardiovascular ones, bordering on statistical significance with respect to the general population.

conclusionsMortality remains significantly high in patients with acromegaly, irrespectively of disease status, as long as the follow-up is sufficiently long with a low rate of patients lost to follow-up. Therapy strategy including radiotherapy does not have an impact on mortality. Oncological causes of death currently outweigh the cardiovascular causes.

Indexed as

AcromegalyAdultAgedFemaleFollow-Up StudiesHumansItalyMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateAcromegalyEpidemiologyIGF1MortalityTherapy

Identifiers

PMID38214852
PMCPMC11142937

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.