Evidence map›Paper›PMID 38214810›Full record

ArticleEuropean journal of pediatrics2024

Multisystem inflammatory syndrome in children (MIS-C): A nationwide collaborative study in the Greek population.

Stavroula Lampidi, Despoina Maritsi, Marietta Charakida, Irini Eleftheriou, Evangelia Farmaki, Nikos Spyridis, Konstantina Charisi, Petrina Vantsi, Filippos Filippatos, Kleopatra Skourti and 22 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 10 institutions in 1 country.

Stavroula LampidiSecond Department of Paediatrics, National and Kapodistrian University of Athens, "P. and A. Kyriakou" Children's Hospital, 11527, Athens, Greece.
Despoina MaritsiSecond Department of Paediatrics, National and Kapodistrian University of Athens, "P. and A. Kyriakou" Children's Hospital, 11527, Athens, Greece.
Marietta CharakidaSecond Department of Paediatrics, National and Kapodistrian University of Athens, "P. and A. Kyriakou" Children's Hospital, 11527, Athens, Greece.
Irini EleftheriouSecond Department of Paediatrics, National and Kapodistrian University of Athens, "P. and A. Kyriakou" Children's Hospital, 11527, Athens, Greece.
Evangelia FarmakiFirst Department of Paediatrics, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642, Thessaloniki, Greece.
Nikos SpyridisSecond Department of Paediatrics, National and Kapodistrian University of Athens, "P. and A. Kyriakou" Children's Hospital, 11527, Athens, Greece.
Konstantina CharisiThird Department of Paediatrics, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642, Thessaloniki, Greece.
Petrina VantsiThird Department of Paediatrics, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642, Thessaloniki, Greece.
Filippos FilippatosFirst Department of Paediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527, Athens, Greece.
Kleopatra SkourtiFirst Department of Paediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527, Athens, Greece.
Efimia Papadopoulou-AlatakiFourth Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56429, Thessaloniki, Greece.
Kyriaki Papadopoulou-LegbelouFourth Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56429, Thessaloniki, Greece.
Parthena KampouridouPediatric Department, Genimatas General Hospital, 54635, Thessaloniki, Greece.
Ioanna N GriveaDepartment of Paediatrics, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500, Larissa, Greece.
Eleni VergadiDepartment of Paediatrics, Medical School, University of Crete, 71003, Heraklion, Greece.
Despoina GkentziDepartment of Paediatrics, University of Patras, University General Hospital of Patras, 26504, Patra, Greece.
Despina DimouPaediatric Department, Penteli Children's Hospital, 15236, Athens, Greece.
Patra KoletsiPaediatric Department, Penteli Children's Hospital, 15236, Athens, Greece.
Lampros FotisThird Department of Paediatrics, National and Kapodistrian University of Athens, General University Hospital "Attikon", 12462, Athens, Greece.
Theodota LiakopoulouIASO Children's Hospital, 15123, Athens, Greece.
Aikaterini AgrafiotouIASO Children's Hospital, 15123, Athens, Greece.
Katerina KourtesiThird Department of Paediatrics, National and Kapodistrian University of Athens, General University Hospital "Attikon", 12462, Athens, Greece.
Georgios TsolasDepartment of Paediatrics, Metropolitan Hospital, 18547, Athens, Greece.
Dimitrios KafetzisDepartment of Paediatrics, Metropolitan Hospital, 18547, Athens, Greece.
Vassiliki PapaevangelouThird Department of Paediatrics, National and Kapodistrian University of Athens, General University Hospital "Attikon", 12462, Athens, Greece.
Gabriel DimitriouDepartment of Paediatrics, University of Patras, University General Hospital of Patras, 26504, Patra, Greece.
Emmanouil GalanakisDepartment of Paediatrics, Medical School, University of Crete, 71003, Heraklion, Greece.
George A SyrogiannopoulosDepartment of Paediatrics, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500, Larissa, Greece.
Vassiliki SpoulouFirst Department of Paediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527, Athens, Greece.
Athanasios MichosFirst Department of Paediatrics, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527, Athens, Greece.
Emmanuel RoilidesThird Department of Paediatrics, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642, Thessaloniki, Greece.
Maria N TsoliaSecond Department of Paediatrics, National and Kapodistrian University of Athens, "P. and A. Kyriakou" Children's Hospital, 11527, Athens, Greece. mariantsolia@gmail.com.
National and Kapodistrian University of Athens · GRAristotle University of Thessaloniki · GRIaso Children’s Hospital · GRMetropolitan Hospital · GRPenteli General Children's Hospital · GRUniversity of Crete · GRUniversity of Thessaly · GRGeneral Hospital of Athens G. Genimatas · GRGeneral University Hospital of Patras · GRUniversity of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe hyperinflammatory condition that may occur following SARS-CoV-2 infection. This retrospective, descriptive study of children hospitalized with multisystem inflammatory syndrome in children (MIS-C) in 12 tertiary care centers from 3/11/2020 to 12/31/2021. Demographics, clinical and laboratory characteristics, treatment and outcomes are described. Among 145 patients (95 males, median age 8.2 years) included, 123 met the WHO criteria for MIS-C, while 112 (77%) had serological evidence of SARS-CoV-2 infection. Fever was present in 99%, gastrointestinal symptoms in 77%, mucocutaneous involvement in 68% and respiratory symptoms in 28%. Fifty-five patients (38%) developed myocarditis, 29 (20%) pericarditis and 19 (13%) coronary aneurysms. Among the above cases 11/55 (20%), 1/29 (3.4%) and 5/19 (26.3%), respectively, cardiac complications had not fully resolved at discharge. Underlying comorbidities were reported in 18%. Median CRP value was 155 mg/l, ferritin 535 ng/ml, PCT 1.6 ng/ml and WBC 14.2 × 10

conclusionMIS-C is a novel, infrequent but serious disease entity. Cardiac manifestations included myocarditis and pericarditis, which resolved in most patients before discharge. Timely initiation of immunomodulatory therapy was shown to be effective. NT-pro-BNP levels may provide a better prediction and monitoring of the disease course. Further research is required to elucidate the pathogenesis, risk factors and optimal management, and long-term outcomes of this clinical entity. WHAT IS KNOWN: • MIS-C is an infrequent but serious disease entity. • Patients with MIS-C present with multi-organ dysfunction, primarily involving the gastrointestinal and cardiovascular systems. WHAT IS NEW: • NT-pro-BNP levels may provide a better prediction and monitoring of the disease course. • Acute kidney injury and/or myocarditis were associated with higher risk of developing shock.

Indexed as

Acute Kidney InjuryCOVID-19MyocarditisPericarditisSystemic Inflammatory Response SyndromeAdrenal Cortex HormonesChildDisease ProgressionGreeceHumansMaleRetrospective StudiesAdrenal Cortex HormonesCOVID-19MIS-CMultisystem inflammatory syndrome in childrenPaediatric inflammatory multisystem syndromePIM-TSSARS-CoV-2

Identifiers

PMID38214810
PMCPMC11001744
OpenAlexW4390789556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.