Evidence map›Paper›PMID 38214806›Full record

ReviewCurrent rheumatology reports2024

Erosive Hand Osteoarthritis: Recent Advances and Future Treatments.

Marta B Bean, Marta Favero, Roberta Ramonda, Carla R Scanzello

Open access · greenAbstract readReview
In one paragraph

Review in Current rheumatology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Behavioral change techniques and patient co-design in programs for hand osteoarthritis: a scoping review with directed content analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2026
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Marta B BeanDivision of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. marta.bean@pennmedicine.upenn.edu.
Marta FaveroRheumatology Unit, Department of Medicine-DIMED, Padova University Hospital, Padova, Italy.
Roberta RamondaRheumatology Unit, Department of Medicine-DIMED, Padova University Hospital, Padova, Italy.
Carla R ScanzelloDivision of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
University of Padua · ITUniversity of Pennsylvania · US

Funding

Modulation of Inflammation in Osteoarthritis via CD14-mediated pattern recognitionR01AR075737 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Carla Rose Scanzello · 2020 to 2026
$2.8M
BCCMA: Cartilage Repair Strategies to Alleviate Arthritis Pain (Care AP): Targeting Pattern-Recognition to Reduce Pain-Related Pathology in OsteoarthritisI01BX004912 · VA · PHILADELPHIA VA MEDICAL CENTER · PI SCANZELLO, CARLA ROSE · 2022 to 2025
–
Achieving Sustained Control of Inflammation to Prevent Post-Traumatic Osteoarthritis (PTOA)I01RX003988 · VA · PHILADELPHIA VA MEDICAL CENTER · PI SCANZELLO, CARLA ROSE · 2023 to 2025
–
Targeting Cellular Mechanosensing to Alleviate Joint Stiffness in Synovial FibrosisI21RX003854 · VA · PHILADELPHIA VA MEDICAL CENTER · PI SCANZELLO, CARLA ROSE · 2022 to 2024
–
BLRD VA I01 BX004912NIAMS NIH HHS R01 AR075737RRD VA I01 RX003988RRD VA I21 RX003854
6 · The paper itself

Abstract

purpose of the reviewErosive hand osteoarthritis (EHOA) is an aggressive form of hand osteoarthritis that leads to significant disability, and recent data suggests that it is increasing in prevalence. This review provides an update of our current understanding of epidemiology, genetic associations, biomarkers, pathogenesis, and treatment of EHOA, with particular focus on studies published within the last 5 years. RECENT

findingsNew studies of EHOA have identified new genetic loci associated with disease, including variants in genes involved in inflammation and bone remodeling. Preclinical studies implicate pathways of innate immunity, including some that may be causal in the condition. Recent novel studies showed that inflammatory features identified by ultrasound and MRI are associated with development of erosive lesions over time on conventional radiography. In the future, these imaging modalities may be useful in identifying patients at risk of adverse outcomes. Promising new findings in genetics, biomarkers, and treatment targets will hopefully allow for future therapeutic options for this debilitating condition.

Indexed as

Hand JointsOsteoarthritisBiomarkersHandHumansInflammationRadiographyBiomarkersBiomarkersDisabilityErosive hand osteoarthritisGeneticsInflammation

Identifiers

PMID38214806
PMCPMC10965372
OpenAlexW4390792883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.