Evidence map›Paper›PMID 38214770›Full record

ArticleArchives of virology2024

Identification of pigeon mitochondrial antiviral signaling protein (MAVS) and its role in antiviral innate immunity.

Qi Shao, Yawen Li, Feiyu Fu, Pei Zhu, Hengan Wang, Zhaofei Wang, Jingjiao Ma, Yaxian Yan, Yuqiang Cheng, Jianhe Sun

Abstract read
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In one paragraph

Article in Archives of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qi ShaoSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.ORCID http://orcid.org/0009-0000-3210-665X
Yawen LiSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
Feiyu FuSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
Pei ZhuSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
Hengan WangSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
Zhaofei WangSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
Jingjiao MaSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
Yaxian YanSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China.
Yuqiang ChengSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China. wyycyq@sjtu.edu.cn.
Jianhe SunSchool of Agriculture and Biology, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai Jiao Tong University, 200240, Shanghai, People's Republic of China. sunjhe@sjtu.edu.cn.

Funding

Wellcome Trust 202212
6 · The paper itself

Abstract

Pigeons can be infected with various RNA viruses, and their innate immune system responds to viral infection to establish an antiviral response. Mitochondrial antiviral signaling protein (MAVS), an important adaptor protein in signal transduction, plays a pivotal role in amplifying the innate immune response. In this study, we successfully cloned pigeon MAVS (piMAVS) and performed a bioinformatics analysis. The results showed that the caspase recruitment domain (CARD) and transmembrane (TM) domain are highly conserved in poultry and mammals but poorly conserved in other species. Furthermore, we observed that MAVS expression is upregulated both in pigeons and pigeon embryonic fibroblasts (PEFs) upon RNA virus infection. Overexpression of MAVS resulted in increased levels of β-interferon (IFN-β), IFN-stimulated genes (ISGs), and interleukin (ILs) mRNA and inhibited Newcastle disease virus (NDV) replication. We also found that piMAVS and human MAVS (huMAVS) induced stronger expression of IFN-β and ISGs when compared to chicken MAVS (chMAVS), and this phenomenon was also reflected in the degree of inhibition of NDV replication. Our findings demonstrate that piMAVS plays an important role in repressing viral replication by regulating the activation of the IFN signal pathway in pigeons. This study not only sheds light on the function of piMAVS in innate immunity but also contributes to a more comprehensive understanding of the innate immunity system in poultry. Our data also provide unique insights into the differences in innate immunity between poultry and mammal.

Indexed as

ColumbidaeImmunity, InnateSignal TransductionAnimalsHumansInterferon-betaMammalsNewcastle disease virusInterferon-betaAntiviral innate immunityIFNMAVSPigeon

Identifiers

PMID38214770

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.