Evidence map›Paper›PMID 38214080›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2024

Seroprevalence of tick-borne encephalitis virus and vaccination coverage of tick-borne encephalitis, Sweden, 2018 to 2019.

Bo Albinsson, Tove Hoffman, Linda Kolstad, Tomas Bergström, Gordana Bogdanovic, Anna Heydecke, Mirja Hägg, Torbjörn Kjerstadius, Ylva Lindroth, Annika Petersson and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Bo AlbinssonZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Tove HoffmanZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Linda KolstadZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Tomas BergströmDepartment of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Gordana BogdanovicDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
Anna HeydeckeCentre for Research and Development, Uppsala University, Region Gävleborg, Gävle, Sweden.
Mirja HäggDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
Torbjörn KjerstadiusLaboratory Medicine, Clinical Microbiology, Central Hospital, Karlstad, Sweden.
Ylva LindrothDepartment of Laboratory Medicine, Medical Microbiology, Lund University, Skåne Laboratory Medicine, Lund, Sweden.
Annika PeterssonDepartment of Clinical Chemistry and Transfusion Medicine, Växjö Central Hospital, Växjö, Sweden.
Marie StenbergLaboratory Medical Center Gotland, Visby hospital, Visby, Sweden.
Sirkka VeneZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Patrik EllströmLaboratory of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden.
Bengt RönnbergZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Åke LundkvistZoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Uppsala University · SEKarolinska University Hospital · SEKarlstad Central Hospital · SELund University · SEUniversity of Gothenburg · SEVäxjö Kommun · SEVisby lasarett · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundIn Sweden, information on seroprevalence of tick-borne encephalitis virus (TBEV) in the population, including vaccination coverage and infection, is scattered. This is largely due to the absence of a national tick-borne encephalitis (TBE) vaccination registry, scarcity of previous serological studies and use of serological methods not distinguishing between antibodies induced by vaccination and infection. Furthermore, the number of notified TBE cases in Sweden has continued to increase in recent years despite increased vaccination.AimThe aim was to estimate the TBEV seroprevalence in Sweden.MethodsIn 2018 and 2019, 2,700 serum samples from blood donors in nine Swedish regions were analysed using a serological method that can distinguish antibodies induced by vaccination from antibodies elicited by infection. The regions were chosen to reflect differences in notified TBE incidence.ResultsThe overall seroprevalence varied from 9.7% (95% confidence interval (CI): 6.6-13.6%) to 64.0% (95% CI: 58.3-69.4%) between regions. The proportion of vaccinated individuals ranged from 8.7% (95% CI: 5.8-12.6) to 57.0% (95% CI: 51.2-62.6) and of infected from 1.0% (95% CI: 0.2-3.0) to 7.0% (95% CI: 4.5-10.7). Thus, more than 160,000 and 1,600,000 individuals could have been infected by TBEV and vaccinated against TBE, respectively. The mean manifestation index was 3.1%.ConclusionA difference was observed between low- and high-incidence TBE regions, on the overall TBEV seroprevalence and when separated into vaccinated and infected individuals. The estimated incidence and manifestation index argue that a large proportion of TBEV infections are not diagnosed.

Indexed as

Encephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneFlavivirus InfectionsAntibodies, ViralHumansSeroepidemiologic StudiesSwedenVaccinationVaccination CoverageAntibodies, Viralnon-structural protein 1seroprevalenceSwedenTick-borne encephalitisvaccination coveragewhole virus

Identifiers

PMID38214080
PMCPMC10785208
OpenAlexW4390791587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.