Evidence map›Paper›PMID 38213979›Full record

ArticleRSC advances2024

Selective fluorescence turn-on detection of combination cisplatin-etoposide chemotherapy based on N-CDs/GSH-CuNCs nanoprobe.

Khalid Alhazzani, Ahmed Z Alanazi, Aya M Mostafa, James Barker, Mohamed M El-Wekil, Al-Montaser Bellah H Ali

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Khalid AlhazzaniDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University Riyadh Saudi Arabia.
Ahmed Z AlanaziDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University Riyadh Saudi Arabia.
Aya M MostafaSchool of Life Sciences, Pharmacy, and Chemistry, Kingston University Kingston-upon-Thames London KT1 2EE UK.
James BarkerSchool of Life Sciences, Pharmacy, and Chemistry, Kingston University Kingston-upon-Thames London KT1 2EE UK.
Mohamed M El-WekilDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University Assiut Egypt Almontaser_bellah@aun.edu.eg.
Al-Montaser Bellah H AliDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University Assiut Egypt Almontaser_bellah@aun.edu.eg.ORCID https://orcid.org/0009-0003-2631-6038
Assiut University · EGKing Saud University · SAKingston University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin (CIS) and etoposide (ETP) combination therapy is highly effective for treating various cancers. However, the potential for pharmacokinetic interactions between these drugs necessitates selective sensing methods to quantitate both CIS and ETP levels in patient's plasma. This work develops a dual fluorescence probe strategy using glutathione-capped copper nanoclusters (GSH-CuNCs) and nitrogen-doped carbon dots (N-CDs) for the simultaneous analysis of CIS and ETP. The fluorescence signal of GSH-CuNCs at 615 nm increased linearly with CIS concentration while the N-CD emission at 480 nm remained unaffected. Conversely, the N-CD fluorescence was selectively enhanced by ETP with no interference with the CuNC fluorescence. Extensive materials characterization including UV-vis, fluorescence spectroscopy, XRD, and TEM confirmed the synthesis of the nanoprobes. The sensor showed high sensitivity with limits of detection of 6.95 ng mL

Identifiers

PMID38213979
PMCPMC10783161
OpenAlexW4390753058

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.