ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Predicting longitudinal basal forebrain volume in the Alzheimer's disease spectrum: the role of sex and ApoE epsilon 4 genotype.Frontiers in neuroscience · 2026Article
- CSF biomarkers of neuroinflammation are associated with regional atrophy.Journal of neurology · 2025Article
- Obesity and Alzheimer's disease dementia: Examining inflammatory links to cognitive decline and neuropsychiatric symptoms.Journal of Alzheimer's disease : JAD · 2025Review
- Body composition and cognitive function in Chinese rural adults: an exploratory factor analysis and network analysis.Frontiers in aging neuroscience · 2025Article
- Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Bayesian analyses for research on Alzheimer's disease and related disorders-updating one's knowledge.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
35 authors at 9 institutions in 5 countries.
Funding
Abstract
introductionWe investigated the association of inflammatory mechanisms with markers of Alzheimer's disease (AD) pathology and rates of cognitive decline in the AD spectrum.
methodsWe studied 296 cases from the Deutsches Zentrum für Neurodegenerative Erkrankungen Longitudinal Cognitive Impairment and Dementia Study (DELCODE) cohort, and an extension cohort of 276 cases of the Alzheimer's Disease Neuroimaging Initiative study. Using Bayesian confirmatory factor analysis, we constructed latent factors for synaptic integrity, microglia, cerebrovascular endothelial function, cytokine/chemokine, and complement components of the inflammatory response using a set of inflammatory markers in cerebrospinal fluid.
resultsWe found strong evidence for an association of synaptic integrity, microglia response, and cerebrovascular endothelial function with a latent factor of AD pathology and with rates of cognitive decline. We found evidence against an association of complement and cytokine/chemokine factors with AD pathology and rates of cognitive decline. DISCUSSION: Latent factors provided access to directly unobservable components of the neuroinflammatory response and their association with AD pathology and cognitive decline.
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Registered trials
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