ArticleIndian journal of anaesthesia2023
Analgesic efficacy of intra-peritoneal instillation of dexamethasone and bupivacaine versus bupivacaine following laparoscopic cholecystectomy - A randomised, double-blind controlled study.
Article in Indian journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Intraperitoneal dexamethasone as an adjuvant to local anesthesia in laparoscopic surgery: A systematic review and meta-analysis of randomized controlled trials.European journal of clinical pharmacology · 2026Pooled it
- Comments on Jaju et al.: Quality of recovery following intraperitoneal bupivacaine with and without dexamethasone in laparoscopic cholecystectomy.Journal of anesthesia · 2026Article
- Quality of recovery following intraperitoneal bupivacaine with and without dexamethasone in laparoscopic cholecystectomy: a randomized controlled trial.Journal of anesthesia · 2026Article
- Post-publication appraisal of randomisation reporting in IJA - Are we hitting the bull's eye?Indian journal of anaesthesia · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Laparoscopy is associated with acute pain. We compared the effectiveness of intra-peritoneal dexamethasone with bupivacaine versus bupivacaine in patients undergoing laparoscopic cholecystectomy for postoperative analgesia. Methods: This randomised study was conducted after approval from the institutional ethics committee and 84 patients were randomly allocated into bupivacaine with dexamethasone group (BD) (received 40 mL of 0.25% bupivacaine with 16 mg dexamethasone), and bupivacaine group (BB) (received 40 mL of 0.25% bupivacaine intra-peritoneally). Data analysis was done using R version 4.2.1. The visual analogue scale (VAS) score, total rescue analgesic dose, and time required for the first analgesic between groups were compared using the Wilcoxon rank sum test or Results: VAS score was significantly lower in the BD group compared to the BB group until 2 h post-operatively with a mean difference of - 1.0 (95% confidence interval [CI] -1.5, -0.53), Conclusion: Intra-peritoneal instillation of 16 mg dexamethasone with 0.25% bupivacaine in laparoscopic cholecystectomy significantly reduces post-operative pain and requirement of rescue analgesic compared to 0.25% bupivacaine alone.
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