Evidence map›Paper›PMID 38213228›Full record

ArticleRenal failure2024

Longitudinal non-targeted metabolomic profiling of urine samples for monitoring of kidney transplantation patients.

Ihsan Yozgat, Ulkem Cakır, Muhittin Abdulkadir Serdar, Sevgi Sahin, Osman Ugur Sezerman, Emirhan Nemutlu, Ahmet Tarik Baykal, Mustafa Serteser

Abstract read
In one paragraph

Article in Renal failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ihsan YozgatDepartment of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.ORCID 0000-0002-0065-4480
Ulkem CakırDepartment of Nephrology, Acibadem University School of Medicine, Istanbul, Turkey.ORCID 0000-0002-8308-7898
Muhittin Abdulkadir SerdarDepartment of Medical Biochemistry, Faculty of Medicine, Acibadem University, Istanbul, Turkey.ORCID 0000-0002-3014-748X
Sevgi SahinDepartment of Nephrology, Acibadem University School of Medicine, Istanbul, Turkey.ORCID 0000-0001-7371-7342
Osman Ugur SezermanDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Acibadem University, Istanbul, Turkey.ORCID 0000-0003-0905-6783
Emirhan NemutluFaculty of Pharmacy, Department of Analytical Chemistry, Hacettepe University, Ankara, Türkiye.ORCID 0000-0002-7337-6215
Ahmet Tarik BaykalDepartment of Medical Biochemistry, Faculty of Medicine, Acibadem University, Istanbul, Turkey.ORCID 0000-0002-8814-7351
Mustafa SerteserDepartment of Medical Biochemistry, Faculty of Medicine, Acibadem University, Istanbul, Turkey.ORCID 0000-0001-7868-7613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assessment of kidney function within the first year following transplantation is crucial for predicting long-term graft survival. This study aimed to develop a robust and accurate model using metabolite profiles to predict early long-term outcomes in patient groups at the highest risk of early graft loss. A group of 61 kidney transplant recipients underwent thorough monitoring during a one-year follow-up period, which included a one-week hospital stay and follow-up assessments at three and six months. Based on their 12-month follow-up serum creatinine levels: Group 2 had levels exceeding 1.5 mg/dl, while Group 1 had levels below 1.5 mg/dl. Metabolites were detected by mass spectrometer and first pre-processed. Univariate and multivariate statistical analyses were employed to identify significant differences between the two groups. Nineteen metabolites were found to differ significantly in the 1

Indexed as

Kidney TransplantationGraft RejectionGraft SurvivalHumansMetabolomicsMultivariate AnalysisbiomarkerdiagnosisKidney transplantationlongitudinal metabolite profilingLong-Term renal graft survivaluntargeted metabolomics

Identifiers

PMID38213228
PMCPMC10791079

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.