Evidence map›Paper›PMID 38213172›Full record

ReviewMini reviews in medicinal chemistry2024

Ferroptosis is Involved in the Pharmacological Effect of Ginsenoside.

Juling Feng, Haodong Chen, Yangbo Liu, Qidi Ai, Yantao Yang, Wenbin He, Lei Zhao, Shifeng Chu, Naihong Chen

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Mini reviews in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Ginsenoside Rg5 mitigates tenocyte deathJournal of ginseng research · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Juling FengHunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China.
Haodong ChenHunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China.
Yangbo LiuHunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China.
Qidi AiHunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China.
Yantao YangHunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China.
Wenbin HeShanxi Key Laboratory of Traditional Chinese Medicine Encephalopathy, Shanxi University of Traditional Chinese Medicine, Taiyuan, 030024, China.
Lei ZhaoResearch lab of translational medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.
Shifeng ChuState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Naihong ChenHunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China.
Hunan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNShanxi University of Traditional Chinese Medicine · CNUniversity of South China · CN

Funding

Beijing Natural Science Foundation 7192135Health and Family Planning Commission of Hunan Province 202104010694Key R&D Program of Shanxi Province 201803D421006National Natural Science Foundation of China 81873026, 82074044, 81730096Natural Science Foundation of Hunan Province 2022JJ80028
6 · The paper itself

Abstract

Ginsenoside is the principal active ingredient in ginseng. Several investigations have found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and antiallergic activities. Ferroptosis is an iron-dependent, non-apoptotic form of cell-regulated death caused by lipid peroxidation. Iron, lipid, and amino acid metabolism orchestrate the complex ferroptosis response through direct or indirect regulation of iron accumulation or lipid peroxidation. More and more research has demonstrated that ginsenoside impacts illnesses via ferroptosis, implying that ferroptosis might be employed as a novel target of ginsenoside for disease therapy. This article examines the molecular mechanism of ferroptosis as well as the current advancement of ginsenoside in influencing disorders via ferroptosis.

Indexed as

FerroptosisGinsenosidesAnimalsAnti-Inflammatory AgentsAntioxidantsHumansIronLipid PeroxidationPanaxAnti-Inflammatory AgentsAntioxidantsGinsenosidesIronamino acid metabolism.ferroptosisGinsenosideiron metabolismlipid metabolismpharmacological target

Identifiers

PMID38213172
PMCPMC11337240
OpenAlexW4390793440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.