Evidence map›Paper›PMID 38213148›Full record

ArticleRecent advances in anti-infective drug discovery2024

Expression of mRNA-TLR-5 Gene in Patients with Endometriosis using Real-time PCR in Tehran, Iran.

Maryam Raghibi, Maliheh Raghibi, Abbas Morovvati, Pegah Shakib, Reza Aflatoonian, Ashkan Dirbaiyan

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Article in Recent advances in anti-infective drug discovery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Maryam RaghibiDepartment of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Maliheh RaghibiDepartment of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Abbas MorovvatiDepartment of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Pegah ShakibRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Reza AflatoonianDepartment of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Ashkan DirbaiyanDepartment of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndometriosis is one of the common diseases of women, especially in reproductive age, and it is one of the most important causes of infertility in women. The aim of this study was to investigate the level of mRNA-TLR-5 expression in women with endometriosis.

methodsThe present study was performed in Nikan Hospital, Tehran, Iran, in 2021. The samples of endometrial mucosa for the eutopic group and an ovarian endometriotic cyst for the ectopic group were obtained from the patients who underwent laparoscopic surgery at the Fetal Infertility Center and were diagnosed with endometriosis. Normal endometrial samples were also obtained from patients who had no history of infertility and underwent laparoscopic TL surgery for reasons other than endometriosis such as ovarian cysts (control group). After RNA extraction and cDNA synthesis, TLR-5 gene expression was evaluated by the Real-Time PCR method.

resultsBased on the results of the comparison of TLR-5 gene expression in all three ectopic, eutopic endometrium, and control groups by Real-Time PCR, it was found that the TLR-5 gene expression is significantly higher in ectopic samples than in the other two groups, but there is a significant difference between two utopic and control groups.

conclusionThe increase in TLR-5 expression in the ectopic group can probably be a reason for reducing the apoptosis of cells entered into the peritoneal cavity and creating an environment for the survival and proliferation of these cells.

Indexed as

EndometriosisReal-Time Polymerase Chain ReactionRNA, MessengerToll-Like Receptor 5AdultCase-Control StudiesEndometriumFemaleHumansIranRNA, MessengerTLR5 protein, humanToll-Like Receptor 5abdomen.Endometrial mucosagene expressionglands and stromareal-time polymerase chain reaction (Real-Time PCR)TLR-5 gene

Identifiers

PMID38213148

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