Evidence map›Paper›PMID 38213144›Full record

Observational studyCombinatorial chemistry & high throughput screening2025

Mechanism of Tonifying Spleen-lung Recipe in the Treatment of Chronic Bronchitis Based on Network Pharmacology and Observational Data.

Hongjin Wu, Shenguang Li, Xiaomei Du, Kaigong Zhu, Jing Li

Abstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Combinatorial chemistry & high throughput screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hongjin WuCentral Laboratory for Science and Technology, Longhua hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Shenguang LiMinhang Integrated Traditional Chinese and Western Medicine Hospital, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Xiaomei DuMinhang Integrated Traditional Chinese and Western Medicine Hospital, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Kaigong ZhuMinhang Integrated Traditional Chinese and Western Medicine Hospital, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Jing LiMinhang Integrated Traditional Chinese and Western Medicine Hospital, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Shanghai University of Traditional Chinese Medicine · CN

Funding

Construction Project of Famous Traditional Chinese Medicine Studio in Minhang District, Shanghai mhmlzy01Special College Construction Project of Traditional Chinese Medicine in Minhang District, Shanghai ZYPP-03
6 · The paper itself

Abstract

backgroundChronic bronchitis is a type of common chronic inflammatory respiratory disease, which is mainly characterized by chronic cough and expectoration. Clinical practice and experimental research have shown that the modified tonifying spleen-lung method has significant preventive and therapeutic effects on chronic lung diseases, but the mechanism of TSLR in the treatment of chronic bronchitis are not yet clear.

objectiveTo explore the mechanism of tonifying spleen-lung recipe (TSLR) in the treatment of chronic bronchitis (CB) through network pharmacology combined with observational studies. MATERIALS AND

methodsThe effective components, core targets and signaling pathways of TSLR in the treatment of chronic bronchitis were obtained using network pharmacology. One hundred and thirty-seven elderly CB patients were selected as the observational group who were treated by TSLR, and 67 no-CB cases from the Physical Examination Center were selected as the control group. We compared the levels of inflammatory parameters between patients before and after TSLR treatment, and after treatment group with the control group were also compared.

resultsThe key effective components of TSLR selected by network pharmacology included quercetin, kaempferol, luteolin, and nobiletin, and the core targets involved HSP90AA1, AKT1, JUN, MAPK1, IL6, MAPK3, MAPK14, STAT1, NFKB1, and CDKN1. KEGG pathway enrichment analysis revealed that the TNF signaling pathway, PI3K-AKT and AGE-RAGE signaling pathways might play a key role in the treatment of CB. The observation study demonstrated that compared with the control group, the levels of WBC, NEU, NLR, PCT, and CRP in the research group after TSLR treatment were increased. Although the levels of WBC, NEU, NLR, and PCT in the research group after TSLR treatment were higher than those in the control group, the above indicators trend tended towards the control group, and there was no significant difference in CRP indicators between the control group and after treatment group.

conclusionTSLR had a good therapeutic effect on chronic bronchitis patients, which might be related to the fact that the natural active components in TSLR inhibit inflammation by regulating the expression of proteins related to PI3K-AKT and TNF signaling pathways.

Indexed as

Bronchitis, ChronicDrugs, Chinese HerbalNetwork PharmacologySpleenAgedFemaleHumansLungMaleMiddle AgedSignal TransductionDrugs, Chinese Herbalchronic bronchitisclinical research.network pharmacologyTonifying spleen-lung recipe

Identifiers

PMID38213144
OpenAlexW4390795543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.