Evidence map›Paper›PMID 38213076›Full record

ArticlePlant biotechnology journal2024

Genomic basis of seed colour in quinoa inferred from variant patterns using extreme gradient boosting.

Felix L Sandell, Thomas Holzweber, Nathaniel R Street, Juliane C Dohm, Heinz Himmelbauer

Open access · goldAbstract read
In one paragraph

Article in Plant biotechnology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  4. Identification ofPlant biotechnology (Tokyo, Japan) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Felix L SandellDepartment of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.
Thomas HolzweberDepartment of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.
Nathaniel R StreetDepartment of Plant Physiology, Umeå Plant Science Centre, Umeå University, Umeå, Sweden.
Juliane C DohmDepartment of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.
Heinz HimmelbauerDepartment of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.ORCID 0000-0001-8897-2928
BOKU University · ATScience for Life Laboratory · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quinoa is an agriculturally important crop species originally domesticated in the Andes of central South America. One of its most important phenotypic traits is seed colour. Seed colour variation is determined by contrasting abundance of betalains, a class of strong antioxidant and free radicals scavenging colour pigments only found in plants of the order Caryophyllales. However, the genetic basis for these pigments in seeds remains to be identified. Here we demonstrate the application of machine learning (extreme gradient boosting) to identify genetic variants predictive of seed colour. We show that extreme gradient boosting outperforms the classical genome-wide association approach. We provide re-sequencing and phenotypic data for 156 South American quinoa accessions and identify candidate genes potentially controlling betalain content in quinoa seeds. Genes identified include novel cytochrome P450 genes and known members of the betalain synthesis pathway, as well as genes annotated as being involved in seed development. Our work showcases the power of modern machine learning methods to extract biologically meaningful information from large sequencing data sets.

Indexed as

Chenopodium quinoaBetalainsColorGenome-Wide Association StudyGenomicsSeedsBetalainsbetalain synthesis pathwaygenome sequencinggenotype‐phenotype relationshipsmachine learningquinoaseed colour

Identifiers

PMID38213076
PMCPMC11022794
OpenAlexW4390794323

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.