Evidence map›Paper›PMID 38212942›Full record

ArticleThe journal of physical chemistry. B2024

Thermodynamics and

Jessica D Carder, Barbara Barile, Krista A Shisler, Francesco Pisani, Antonio Frigeri, K W Hipps, Grazia Paola Nicchia, James A Brozik

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jessica D CarderDepartment of Chemistry, Washington State University, PO Box 644630, Pullman, Washington 99164-4630, United States.ORCID 0000-0002-2194-3169
Barbara BarileDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Bari 70124, Italy.ORCID 0000-0002-5093-6662
Krista A ShislerDepartment of Chemistry, Washington State University, PO Box 644630, Pullman, Washington 99164-4630, United States.
Francesco PisaniDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Bari 70124, Italy.
Antonio FrigeriDepartment of Translational Medicine and Neuroscience, University of Bari Aldo Moro, Bari 70124, Italy.
K W HippsDepartment of Chemistry, Washington State University, PO Box 644630, Pullman, Washington 99164-4630, United States.ORCID 0000-0002-5944-5114
Grazia Paola NicchiaDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Bari 70124, Italy.
James A BrozikDepartment of Chemistry, Washington State University, PO Box 644630, Pullman, Washington 99164-4630, United States.ORCID 0000-0003-2097-5051
Washington State University · USAlbert Einstein College of Medicine · USUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aquaporin-4 (AQP4) is a water channel protein found primarily in the central nervous system (CNS) that helps to regulate water-ion homeostasis. AQP4 exists in two major isoforms: M1 and M23. While both isoforms have a homotetrameric quaternary structure and are functionally identical when transporting water, the M23 isoform forms large protein aggregates known as orthogonal arrays of particles (OAPs). In contrast, the M1 isoform creates a peripheral layer around the outside of these OAPs, suggesting a thermodynamically stable interaction between the two. Structurally, the M1 isoform has an N-terminal tail that is 22 amino acids longer than the M23 isoform and contains two solvent-accessible cysteines available for

Indexed as

CysteineLipoylationAquaporin 4HumansProtein IsoformsThermodynamicsWaterAquaporin 4CysteineProtein IsoformsWater

Identifiers

PMID38212942
PMCPMC10824246
OpenAlexW4390792865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.