Evidence map›Paper›PMID 38212847›Full record

ArticleBMC nutrition2024

Daily yogurt consumption does not affect bone turnover markers in men and postmenopausal women of Caribbean Latino descent: a randomized controlled trial.

Lindsay McGrail, Daniela Vargas-Robles, Mayra Rojas Correa, Lisa C Merrill, Sabrina E Noel, Martha Velez, Ana Maldonado-Contreras, Kelsey M Mangano

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05350579 (Identifying Mechanisms Underpinning the Impact of Daily Yogurt Supplementation on the Gut Microbiome, Inflammation and Bone Biomarkers in Older Adults), which is not on this map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05350579 naterminatednot on this map

Identifying Mechanisms Underpinning the Impact of Daily Yogurt Supplementation on the Gut Microbiome, Inflammation and Bone Biomarkers in Older Adults

TypeinterventionalSponsorUniversity of Massachusetts, LowellRan2019 to 2020Enrolled33ConditionsOsteoporosis, InflammationArmsYogurt Intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lindsay McGrailDepartment of Biomedical and Nutritional Sciences, University of Massachusetts, 3 Solomont Way, Lowell, MA, 01832, USA.
Daniela Vargas-RoblesDepartment of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Mayra Rojas CorreaDepartment of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Lisa C MerrillDepartment of Biomedical and Nutritional Sciences, University of Massachusetts, 3 Solomont Way, Lowell, MA, 01832, USA.
Sabrina E NoelDepartment of Biomedical and Nutritional Sciences, University of Massachusetts, 3 Solomont Way, Lowell, MA, 01832, USA.
Martha VelezDepartment of Health and Human Services, City of Lawrence, Lawrence, MA, USA.
Ana Maldonado-ContrerasDepartment of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kelsey M ManganoDepartment of Biomedical and Nutritional Sciences, University of Massachusetts, 3 Solomont Way, Lowell, MA, 01832, USA. kelsey_mangano@uml.edu.
University of Massachusetts Lowell · USUniversity of Massachusetts Chan Medical School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCaribbean Latino adults are at high risk for osteoporosis yet remain underrepresented in bone research. This increased risk is attributed to genetics, diet, and lifestyle known to drive inflammation and microbial dysbiosis.

objectiveThe primary objective of this study was to determine whether consuming 5 oz of yogurt daily for 8wks improves bone turnover markers (BTMs) among Caribbean Latino adults > 50 years; and secondarily to determine the impact on the gut microbiota and markers of intestinal integrity and inflammation.

methodsFollowing a 4wk baseline period, participants were randomized to an 8wk whole fat yogurt intervention (n = 10) daily, containing only Streptococcus thermophilus and Lactobacillus bulgaricus, or to an untreated control group that did not consume yogurt (n = 10). Blood and stool samples collected at week-0 and week-8 were used to assess BTMs, inflammation, intestinal integrity biomarkers, and gut microbiota composition, short chain fatty acids (SCFAs), respectively. Data were evaluated for normality and statistical analyses were performed.

resultsParticipants were 55% women, with a mean age of 70 ± 9 years, BMI 30 ± 6 kg/m

conclusionsIn this study, daily yogurt did not improve BTMs, inflammation, intestinal integrity, nor SCFAs. However, yogurt did influence beta diversity, or the abundance of rare taxa within the gut microbiota of the yogurt group, compared to controls. Additional research to identify dietary approaches to reduce osteoporosis risk among Caribbean Latino adults is needed.

trial registrationThis study is registered to ClinicalTrials.gov, NCT05350579 (28/04/2022).

Indexed as

AgingBone turnover markersGut microbiotaInflammationYogurt

Identifiers

PMID38212847
PMCPMC10785535
OpenAlexW4390753528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.