ArticleLipids in health and disease2024
The association between dyslipidaemia in the first trimester and adverse pregnancy outcomes in pregnant women with subclinical hypothyroidism: a cohort study.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 9 citations in OpenAlex.
- Lipid profiles and risk of gestational diabetes mellitus in women with isolated TPOAb positivity during early pregnancy.Scientific reports · 2026Article
- Role of second-trimester hematological and biochemical indicators in predicting preeclampsia: a retrospective study.BMC pregnancy and childbirth · 2026Article
- Trimester-specific association of gestational Atherogenic Index of Plasma (AIP) with adverse pregnancy outcomes among women with and without GDM: a cohort study.BMC endocrine disorders · 2026Article
- Article
- Exploring hypothyroidism's effects on lipid profiles: Evidence of metabolic consequences in subclinical disease.Saudi medical journal · 2025Article
- Predictivity of Hepatic Steatosis Index for Gestational Hypertension and Preeclampsia: a Prospective Cohort Study.International journal of medical sciences · 2025Article
- Serum Uric Acid-to-Serum Creatinine Ratio, Thyroid Function, and Gestational Diabetes Mellitus Risk during Early Pregnancy among Chinese Women.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Subclinical Hypothyroidism and Gestational Hypertensive Disorders in a Cohort of Romanian Pregnant Women with Gestational Diabetes Mellitus: A Pilot Study.Biomedicines · 2024Article
- Serum triglyceride to high density lipoprotein cholesterol ratio in late pregnancy as a potential predictor of adverse birth outcomes: an analysis of real-world data.Diabetology & metabolic syndrome · 2024Article
- The association of early pregnancy dyslipidemia with preterm birth in twin pregnancies: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- Lipid Metabolism in Pregnancy Women with Hypothyroidism and Potential Influence on Pregnancy Outcome.Journal of lipids · 2024Review
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16 authors at 2 institutions in 1 country.
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Abstract
backgroundSubclinical hypothyroidism (SCH) is linked to dyslipidaemia and adverse pregnancy outcomes. However, the impact of dyslipidaemia on the outcome of pregnancy in SCH is unclear.
methodsWe enrolled 36,256 pregnant women and evaluated their pregnancy outcomes. The following data was gathered during the first trimester (≤ 13
resultsIn the first trimester, LDL-C > 3.24 mmol/L, TG > 1.92 mmol/L, HDL-C < 1.06 mmol/L, and TC > 5.39 mmol/L were used to define dyslipidaemia. In this cohort, 952 (3.56%) patients were diagnosed with SCH, and those who had dyslipidaemia in the first trimester had higher incidences of gestational hypertension (6.59% vs. 3.25%), preeclampsia/eclampsia (7.14% vs. 3.12%), GDM (22.53% vs. 13.77%), and low birth weight (4.95% vs. 2.08%) than did those without dyslipidaemia. However, after adjusting for prepregnancy body mass index (pre-BMI), dyslipidaemia was no longer related to these risks. Furthermore, elevated TG dyslipidaemia in SCH patients was connected to an enhanced potential of gestational hypertension (odds ratio [OR]: 2.687, 95% confidence interval [CI]: 1.074 ~ 6.722), and elevated LDL-C dyslipidaemia correlated with increased preeclampsia/eclampsia risk (OR: 3.172, 95% CI: 1.204 ~ 8.355) after accounting for age, smoking status, alcohol use, pre-BMI, and levothyroxine use. Additionally, the combination of TC, TG, LDL-C, pre-BMI, and TSH exhibited enhanced predictive capabilities for gestational hypertension, preeclampsia/eclampsia, and GDM. Values of 0.767, 0.704, and 0.706 were obtained from the area under the curve.
conclusionsAmong pregnant women with SCH, dyslipidaemia in early pregnancy was related to elevated risks of adverse pregnancy consequences. The combined consideration of age, pre-BMI, TSH, and lipid levels in the first trimester could be beneficial for monitoring patients and implementing interventions to reduce adverse pregnancy outcomes.
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