Evidence map›Paper›PMID 38212655›Full record

ArticleNature communications2024

Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy.

Mengmeng Xia, Qiyue Wang, Yamin Liu, Chunyan Fang, Bo Zhang, Shengfei Yang, Fu Zhou, Peihua Lin, Mingzheng Gu, Canyu Huang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. An In Situ HAdvanced materials (Deerfield Beach, Fla.) · 2026
    Article
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  13. Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Mengmeng Xia *School of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal University, 241000, Wuhu, China.
Qiyue Wang *Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, 200240, Shanghai, China.
Yamin Liu *Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, 200240, Shanghai, China.ORCID 0000-0001-7344-1788
Chunyan Fang *Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, 200240, Shanghai, China.
Bo ZhangFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, 200240, Shanghai, China.ORCID 0000-0002-1579-3707
Shengfei YangInstitute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
Fu ZhouSchool of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal University, 241000, Wuhu, China.ORCID 0000-0002-9270-048X
Peihua LinFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, 200240, Shanghai, China.ORCID 0009-0006-6230-9689
Mingzheng GuSchool of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal University, 241000, Wuhu, China.
Canyu HuangFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, 200240, Shanghai, China.
Xiaojun ZhangSchool of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal University, 241000, Wuhu, China.ORCID 0000-0003-2925-8665
Fangyuan LiInstitute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China. lfy@zju.edu.cn.
Hongying LiuCollege of Automation, Hangzhou Dianzi University, 310018, Hangzhou, China. liuhongying@hdu.edu.cn.ORCID 0000-0002-4186-2657
Guangfeng WangSchool of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal University, 241000, Wuhu, China. wangyuz@mail.ahnu.edu.cn.
Daishun LingFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, 200240, Shanghai, China. dsling@sjtu.edu.cn.ORCID 0000-0002-9977-0237
Shanghai Jiao Tong University · CNAnhui Normal University · CNHangzhou Dianzi University · CNSongjiang District Central Hospital · CNUnivates · BRZhejiang University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21936001, 21675001, 21976004, 32071374
6 · The paper itself

Abstract

Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate the introduction of synthetic functional groups as bioorthogonal handles on the nanoparticles, leading to complex and laborious design processes. Here, we report the synthesis of tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS nanoparticles (CuS-I@P1 NPs) as self-catalytic building blocks that undergo self-propelled assembly inside tumour cells via Tyr-Tyr condensation reactions catalyzed by the nanoparticles themselves. Upon cellular internalization, the CuS-I@P1 NPs undergo furin-guided condensation reactions, leading to the formation of CuS-I nanoparticle assemblies through dityrosine bond. The tumour-specific furin-instructed intracellular assembly of CuS-I NPs exhibits activatable dual-modal imaging capability and enhanced photothermal effect, enabling highly efficient imaging and therapy of tumours. The robust nanoparticle self-catalysis-regulated in situ assembly, facilitated by natural handles, offers the advantages of convenient fabrication, high reaction specificity, and biocompatibility, representing a generalizable strategy for target-specific activatable biomedical imaging and therapy.

Indexed as

NanoparticlesNeoplasmsCatalysisCopperFurinHumansPhototherapyCopperFurin

Identifiers

PMID38212655
PMCPMC10784296
OpenAlexW4390741065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.