Evidence map›Paper›PMID 38212622›Full record

ArticleScientific reports2024

Time-course changes in fingernail cortisol levels during pregnancy and postpartum.

Shuhei Izawa, Mikiko Kawasaki, Nagisa Sugaya, Shusaku Nomura

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shuhei IzawaOccupational Stress and Health Management Research Group, National Institute of Occupational Safety and Health, Kawasaki, Japan. izawa@h.jniosh.johas.go.jp.
Mikiko KawasakiGraduate School of Medicine, International University of Health and Welfare, Tokyo, Japan.
Nagisa SugayaOccupational Stress and Health Management Research Group, National Institute of Occupational Safety and Health, Kawasaki, Japan.
Shusaku NomuraFaculty of Engineering, Nagaoka University of Technology, Nagaoka, Japan. nomura@kjs.nagaokaut.ac.jp.

Funding

Japan Society for the Promotion of Science JP17H02656
6 · The paper itself

Abstract

The cortisol level in fingernails can reflect the cumulative hormones produced in the body several months prior. However, previous studies have only demonstrated the cross-sectional associations of fingernail cortisol with salivary or hair cortisol, and not longitudinal changes in fingernail cortisol in situations where cortisol levels in the body could be expected to change. Therefore, this study focused on pregnancy as a model for changes in cortisol levels over a prolonged period of time, and investigating the time courses of fingernail cortisol during pregnancy and the postpartum period. We collected nail samples from 30 healthy women during pregnancy and 12 months postpartum to measure the cortisol levels in the nail. Results showed that cortisol levels in fingernail clippings increased from 1 month before childbirth to 4 months postpartum, with the levels peaking at 2 months postpartum. Additionally, we found higher cortisol levels in fingernail clippings in primiparas than in those of multiparas. The time course of fingernail cortisol levels could replicate the longitudinal changes in cortisol in the body, and differences between multiparas and primiparas seemed to be biologically plausible, which could support the concept of fingernail cortisol as a retrospective index of hormone production.

Indexed as

HydrocortisoneNailsCross-Sectional StudiesFemaleHumansPostpartum PeriodPregnancyRetrospective StudiesHydrocortisone

Identifiers

PMID38212622
PMCPMC10784579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.