ReviewInflammopharmacology2024
Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies.
Review in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Immunomodulatory Tissue-Engineering Strategies for Diabetic Foot Ulcer Management: A Systematic Review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- Effect of Huiyang Shengji unguent on the NOD-like receptor family pyrin domain containing protein 3/caspase1/ gasdermin D pathway and lymphatic angiogenesis in patients with diabetic foot ulcer.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Trial
- Accelerated Wound Healing with a Bilayer Biodegradable Synthetic Matrix in Post-Surgical Diabetes-Related Foot Wounds: A Randomised Controlled Trial.Biomedicines · 2026Article
- [Effects of astragaloside Ⅰ on full-thickness skin defects in diabetic rats and its underlying mechanism].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Research progress on coronary heart disease and cytokines: mechanisms, clinical implications, and future directions.Journal of cardiothoracic surgery · 2026Review
- Protective effect of tectorigenin against streptozotocin-induced gestational diabetes mellitus in rats via alteration of inflammation, oxidative stress, HO-1/Nrf2 and NF-κB/COX-2/iNOS signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- pH/glucose dual-responsive drug release hydrogel loaded with tannic acid and gallium ions enhances diabetic wound healing upon bacterial infection.Journal of biological engineering · 2026Article
- Towards a standardized diabetic prolonged wound healing model in hairless SKH1 mice.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Article
- A Review of Medicinal Plants from the Anak Dalam Tribe of Jambi: An Evaluation of Their Potential for Diabetic Wound Healing Effects-Current Status and Future Perspectives.Drug design, development and therapy · 2026Review
- Multidimensional Regulatory Mechanisms and Targeted Therapeutic Strategies for Inhibited Keratinocyte Proliferation in Diabetic Wounds.Drug design, development and therapy · 2026Review
- Biomaterials-mediated sequential drug delivery: Emerging trends for wound healing.Asian journal of pharmaceutical sciences · 2025Review
- Feather-inspired janus interfaces with spatiotemporal ionic programming for diabetic wound infection control and regenerative healing.Materials today. Bio · 2025Article
- Type 2 Diabetes-Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through βAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mechanisms of lncRNA in Diabetic Foot Ulcer Wound Healing.The journal of gene medicine · 2025Review
- [Research on the pathogenesis and treatment of diabetic foot ulcer wounds].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Review
- Wireless Power-Up and Readout of Label-Free Nanosensors for In-Vivo Monitoring of Protein Concentrations in Live Animals.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Bioinspired wearable polymer microneedle patches: pioneering diabetic wound therapy for the horizon.RSC advances · 2025Review
- 3D TGF-β1-expressing mesenchymal stem cells enhance wound healing in a diabetic mouse model.Stem cell research & therapy · 2025Article
- Understanding molecular mechanism of diabetic wound healing: addressing recent advancements in therapeutic managements.Journal of diabetes and metabolic disorders · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is a prevalent cause of mortality worldwide and can lead to several secondary issues, including DWs, which are caused by hyperglycemia, diabetic neuropathy, anemia, and ischemia. Roughly 15% of diabetic patient's experience complications related to DWs, with 25% at risk of lower limb amputations. A conventional management protocol is currently used for treating diabetic foot syndrome, which involves therapy using various substances, such as bFGF, pDGF, VEGF, EGF, IGF-I, TGF-β, skin substitutes, cytokine stimulators, cytokine inhibitors, MMPs inhibitors, gene and stem cell therapies, ECM, and angiogenesis stimulators. The protocol also includes wound cleaning, laser therapy, antibiotics, skin substitutes, HOTC therapy, and removing dead tissue. It has been observed that treatment with numerous plants and their active constituents, including Globularia Arabica, Rhus coriaria L., Neolamarckia cadamba, Olea europaea, Salvia kronenburgii, Moringa oleifera, Syzygium aromaticum, Combretum molle, and Myrtus communis, has been found to promote wound healing, reduce inflammation, stimulate angiogenesis, and cytokines production, increase growth factors production, promote keratinocyte production, and encourage fibroblast proliferation. These therapies may also reduce the need for amputations. However, there is still limited information on how to prevent and manage DWs, and further research is needed to fully understand the role of alternative treatments in managing complications of DWs. The conventional management protocol for treating diabetic foot syndrome can be expensive and may cause adverse side effects. Alternative therapies, such as medicinal plants and green synthesis of nano-formulations, may provide efficient and affordable treatments for DWs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.