Evidence map›Paper›PMID 38212450›Full record

ArticleArchives of toxicology2024

Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT.

Elisabeth Varga, Hélène-Christine Prause, Matthias Riepl, Nadine Hochmayr, Deniz Berk, Eva Attakpah, Endre Kiss, Nikola Medić, Giorgia Del Favero, Thomas Ostenfeld Larsen and 2 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 19 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Elisabeth Varga *Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria. elisabeth.varga@vetmeduni.ac.at.ORCID 0000-0001-6046-3259
Hélène-Christine Prause *Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria.ORCID 0009-0004-4772-1996
Matthias RieplDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria.
Nadine HochmayrDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria.
Deniz BerkDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria.
Eva AttakpahDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria.
Endre KissDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria.
Nikola MedićMarine Biological Section, Department of Biology, University of Copenhagen, Strandpromenaden 5, 3000, Helsingør, Denmark.ORCID 0000-0003-3222-3797
Giorgia Del FaveroDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria.ORCID 0000-0001-8633-5458
Thomas Ostenfeld LarsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 221, 2800 Kgs, Lyngby, Denmark.ORCID 0000-0002-3362-5707
Per Juel HansenMarine Biological Section, Department of Biology, University of Copenhagen, Strandpromenaden 5, 3000, Helsingør, Denmark.ORCID 0000-0003-0228-9621
Doris MarkoDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Str. 38-40, 1090, Vienna, Austria.ORCID 0000-0001-6568-2944
University of Vienna · ATUniversity of Copenhagen · DKTechnical University of Denmark · DK

Funding

Austrian Science Fund I-5707Austrian Science Fund J3895-N28Austrian Science Fund FWF J 3895H2020 Marie Skłodowska-Curie Actions 766327Innovationsfonden 0603-00449BInnovationsfonden 4097-00007B
6 · The paper itself

Abstract

Harmful algal blooms kill fish populations worldwide, as exemplified by the haptophyte microalga Prymnesium parvum. The suspected causative agents are prymnesins, categorized as A-, B-, and C-types based on backbone carbon atoms. Impacts of P. parvum extracts and purified prymnesins were tested on the epithelial rainbow trout fish gill cell line RTgill-W1 and on the human colon epithelial cells HCEC-1CT. Cytotoxic potencies ranked A > C > B-type with concentrations spanning from low (A- and C-type) to middle (B-type) nM ranges. Although RTgill-W1 cells were about twofold more sensitive than HCEC-1CT, the cytotoxicity of prymnesins is not limited to fish gills. Both cell lines responded rapidly to prymnesins; with EC

Indexed as

CholestenesHaptophytaLipoproteinsAnimalsCell LineColonEpithelial CellsGillsHumans3-hydroxycholest-7-ene-14-carbaldehydeCholestenesLipoproteinsprymnesinFluorescence microscopyIchthyotoxinIonoregulationMicroalgaeMSUHPLC

Identifiers

PMID38212450
PMCPMC10861388
OpenAlexW4390754541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.