Evidence map›Paper›PMID 38212439›Full record

ArticleScientific reports2024

A high-performance polymer composite column for coronavirus nucleic acid purification.

Akli Zarouri, Aaron M T Barnes, Hamada Aboubakr, Vinni Thekkudan Novi, Qiuchen Dong, Andrew Nelson, Sagar Goyal, Abdennour Abbas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Akli ZarouriDepartment of Bioproducts and Biosystems Engineering, University of Minnesota Twin Cities, 2004 Folwell Ave, Saint Paul, MN, USA.
Aaron M T BarnesDivision of Molecular Pathology and Genomics, Department of Laboratory Medicine and Pathology, University of Minnesota Twin Cities, 420 Delaware Street SE, Minneapolis, MN, USA.
Hamada AboubakrDepartment of Bioproducts and Biosystems Engineering, University of Minnesota Twin Cities, 2004 Folwell Ave, Saint Paul, MN, USA.
Vinni Thekkudan NoviDepartment of Bioproducts and Biosystems Engineering, University of Minnesota Twin Cities, 2004 Folwell Ave, Saint Paul, MN, USA.
Qiuchen DongDepartment of Bioproducts and Biosystems Engineering, University of Minnesota Twin Cities, 2004 Folwell Ave, Saint Paul, MN, USA.
Andrew NelsonDivision of Molecular Pathology and Genomics, Department of Laboratory Medicine and Pathology, University of Minnesota Twin Cities, 420 Delaware Street SE, Minneapolis, MN, USA.
Sagar GoyalDepartment of Veterinary Population Medicine, University of Minnesota Twin Cities, 1333 Gortner Ave., Saint Paul, MN, USA.
Abdennour AbbasDepartment of Bioproducts and Biosystems Engineering, University of Minnesota Twin Cities, 2004 Folwell Ave, Saint Paul, MN, USA. aabbas@umn.edu.
University of Minnesota · USUniversity of Minnesota Medical Center · US

Funding

Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
NIAID NIH HHS T32 AI055433
6 · The paper itself

Abstract

Here, we report the development of a novel polymer composite (PC) purification column and kit. The performance of the PC columns was compared to conventional silica gel (SG) columns for the purification of nucleic acids from coronaviruses, including SARS-CoV-2, in 82 clinical samples. The results shows that PC-based purification outperforms silica gel (SG)-based purification by enabling a higher sensitivity (94%), accuracy (97%), and by eliminating false positives (100% specificity). The high specificity is critical for efficient patient triage and resource management during pandemics. Furthermore, PC-based purification exhibits three times higher analytical precision than a commonly used SG-based nucleic acid purification thereby enabling a more accurate quantification of viral loads and higher reproducibility.

Indexed as

COVID-19Nucleic AcidsHumansReproducibility of ResultsSARS-CoV-2Sensitivity and SpecificitySilica GelNucleic AcidsSilica Gel

Identifiers

PMID38212439
PMCPMC10784286
OpenAlexW4390755343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.